Several neurological disorders are associated with the aggregation of aberrant proteins, often localized in intracellular organelles such as the endoplasmic reticulum. Here we study protein aggregation kinetics by mean-field reactions and three dimensional Monte carlo simulations of diffusion-limited aggregation of linear polymers in a confined space, representing the endoplasmic reticulum. By ...

A significant lag phase was observed in the accumulation of product for the reaction catalyzed by pyruvate decarboxylase (PDC) purified from mature maize kernels. The effects of pH, pyruvate, potassium chloride, PDC concentration, and Mg(2+)-thiamine pyrophosphate upon this lag and upon the observed cooperativity were investigated. PDC preincubated with Mg(2+)-thiamine pyrophosphate for six day...

Understanding resistance to antifungal agents in Aspergillus fumigatus is of increasing importance for the treatment of invasive infections in immunocompromised patients. Although a number of molecular resistance mechanisms are described in detail, the potential accompanying virulence changes and impact on clinical outcome have had little attention. We developed a new measure of survival, the c...

We investigated protein and gene expression in the lag phase of Lactococcus lactis subsp. lactis CNRZ 157 and compared it to the exponential and stationary phases. By means of two-dimensional polyacrylamide gel electrophoresis, 28 highly expressed lag-phase proteins, implicated in nucleotide metabolism, glycolysis, stress response, translation, transcription, cell division, amino acid metabolis...

In this paper we study the spatial behavior of solutions to the equations obtained by taking formal Taylor approximations to the heat conduction dual-phase-lag and three-phaselag theories, reflecting Saint-Venant’s principle. Depending on the relative order of derivation with respect to the time we propose different arguments. One is inspired by the arguments for parabolic problems and the othe...

The existence of a lag phase during the gastric emptying of solid foods is controversial. It has been hypothesised that among other early events, the stomach requires a period of time to process solid food to particles small enough to be handled as a liquid. At present no standardised curve fitting techniques exist for the characterisation and quantification of the lag phase or the emptying rat...

In the present work, a modified model of heat conduction including higher order of time derivative is derived by extending Green and Naghdi theory without energy dissipation. We introduce two phase lag times to include the thermal displacement gradient and the heat flux in the heat conduction and depict microscopic responses more precisely. The constructed model is applied to s...

*Correspondence: Nikolai Lebedev and Leonard M. Tender , 4555 Overlook Avenue, SW, Washington, DC, USA e-mail: [email protected]; [email protected] Atomic force microscopy and confocal resonance Raman microscopy (CRRM) of singlecells were used to study the transition of anode-grown Geobacter sulfurreducens biofilms from lag phase (initial period of low current) to exponenti...