Triple-negative breast cancers (TNBC) lacking estrogen and progesterone receptors and HER2 amplification have a relatively high risk of metastatic dissemination, but the mechanistic basis for this risk is not understood. Here, we report that serum levels of CD95 ligand (CD95L) are higher in patients with TNBC than in other patients with breast cancer. Metalloprotease-mediated cleavage of CD95L ...

The adhesion of cancer cells to vascular endothelium is a critical process in hematogenous metastasis and might be similar the recruitment leukocytes at site inflammation. It mediated by E-selectin its ligands, which most stereospecific glycoconjugate sialyl Lewis x (CD15s), may expressed as an oligosaccharide branch CD44 glycoprotein, well self-contained glycosphingolipid. also known that incr...

*Correspondence to: Powel H Brown, Email: [email protected] Submitted: 06/20/13; Accepted: 06/24/13 http://dx.doi.org/10.4161/cc.25871 Comment on: Hartman ZC, et al. Cancer Res 2013; 73:3470-80; PMID:23633491; http://dx.doi.org/10.1158/0008-5472.CAN-12-4524-T Breast cancer is second only to nonmelanoma skin cancers as the most prevalent and lethal malignancy among women worldwide. Upon dia...

Objective: Triple-negative breast cancers (TNBCs) are associated with younger age, advanced stage at diagnosis, ethnicity, lower socioeconomic status (SES), and poor prognosis. The aim of the study was to investigate clinicopathologic features TNBC patients living in Southeastern Anatolia, association between cultural factors TNBC. 
 Material Methods: A total 875 women were included study....

Background: Triple-negative breast cancer (TNBC) is defined as absent expression of estrogen receptor (ER) and progesterone receptors human epidermal growth factor (HER2neu). These cancers are associated with poor prognosis. Aims Objectives: We aimed at to study the clinicopathological profile survival among women TNBC. Materials Methods: The was conducted over a period 4 years. Surgical specim...

Introduction Triple-negative breast cancer (TNBC) is clinically defined as breast tumors lacking expression of estrogen receptor (ER) and progesterone receptor, with normal human epidermal growth factor receptor type 2 (HER2) gene copy number and expression. It accounts for approximately 15% to 20% of all breast cancers and is more prevalent in younger women and in African-American women. TNBC ...

The majority of triple-negative breast cancers (TNBCs) are basal-like breast cancers. However there is no reported study on anti-tumor effects of sunitinib in xenografts of basal-like TNBC (MDA-MB-468) cells. In the present study, MDA-MB-231, MDA-MB-468, MCF-7 cells were cultured using RPMI 1640 media with 10% FBS. Vascular endothelia growth factor (VEGF) protein levels were detected using ELIS...

Triple-negative breast cancer (TNBC) is a type of highly aggressive that hard to be cured by the commonly used chemotherapy, mainly due lack effective tumor targeting ability current drugs and TNBC drug resistance. Therefore, development novel strategies for precise high-efficient therapy TNBCs urgently needed. In present work, multifunctional magnetic gold nanoheterostructure with photosensiti...

Checkpoint inhibitors are a type of immune therapy used to treat different types cancers. These drugs block checkpoint proteins, for example, CTLA-4, PD-1, and PD-L1 inhibitors. They proteins that stop the system from attacking cancer cells. Checkpoints also described as monoclonal antibody antagonizes binding between B7 CTLA-4 PD-1. Immune BARCA mutated triple-negative breast (TNBCS) in patien...

Single progesterone receptor positive (PgRþ), especially in form of ER /PgRþ/HER2 , is a nonnegligible phenomenon. Little is known about the characteristics and the role of single PgR positive in this phenotype. Therefore, we explore the significance of single PgR positivity by comparing ER /PgRþ/HER2 breast cancers with triple negative breast cancers (TNBCs). Three thousand nine hundred sixty-...