نتایج جستجو برای: tnbcs

تعداد نتایج: 265  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2016
Franca Podo Filippo Santoro Giovanni Di Leo Siranoush Manoukian Clelia de Giacomi Stefano Corcione Laura Cortesi Luca A Carbonaro Rubina M Trimboli Anna Cilotti Lorenzo Preda Bernardo Bonanni Matilde Pensabene Laura Martincich Antonella Savarese Alma Contegiacomo Francesco Sardanelli

PURPOSE To compare phenotype features and survival of triple-negative breast cancers (TNBC) versus non-TNBCs detected during a multimodal annual screening of high-risk women. EXPERIMENTAL DESIGN Analysis of data from asymptomatic high-risk women diagnosed with invasive breast cancer during the HIBCRIT-1 study with median 9.7-year follow-up. RESULTS Of 501 enrolled women with BRCA1/2 mutatio...

2016
Franca Podo Filippo Santoro Giovanni Di Leo Siranoush Manoukian Clelia de Giacomi Stefano Corcione Laura Cortesi Luca A. Carbonaro Rubina M. Trimboli Anna Cilotti Lorenzo Preda Bernardo Bonanni Matilde Pensabene Francesco Sardanelli

Purpose: To compare phenotype features and survival of triple-negative breast cancers (TNBC) versus non-TNBCs detected during a multimodal annual screening of high-risk women. Experimental Design: Analysis of data from asymptomatic high-risk women diagnosed with invasive breast cancer during the HIBCRIT-1 study with median 9.7-year follow-up. Results: Of 501 enrolled women with BRCA1/2 mutation...

Journal: :The oncologist 2017
Clinton Yam Sendurai A Mani Stacy L Moulder

Triple negative breast cancers (TNBCs) represent 10%-20% of primary breast cancers, and despite having greater initial sensitivity to cytotoxic chemotherapy, patients with TNBCs have higher rates of distant metastasis and a poorer prognosis compared with patients with hormone receptor positive and/or human epidermal growth factor receptor 2 positive disease. TNBC has historically been treated a...

2017
Adriana-Andreea Jitariu Anca Maria Cîmpean Domenico Ribatti Marius Raica

One of the most controversial women malignancies, triple negative breast cancers (TNBCs) are critically overviewed here, being focused on data useful in clinical practice or to improve the therapy and patients survival. TNBCs "choose" young women and its "kiss" is, unfortunately deadly in most cases. Currently, few sparse data are available in literature concerning the origins of TNBC. Vasculog...

2016
Tian Tian Miao Ruan Wentao Yang Ruohong Shui

Tumor-infiltrating lymphocytes (TILs) may be associated with clinical outcome in triple-negative breast cancers (TNBCs). However, lacking of standardized methodologies in TILs evaluation has hindered its application in clinical practice. To evaluate the prognostic role of TILs scored by methods recommended by International TILs Working Group 2014, we performed a retrospective study of TILs in 4...

2013
Rounak Nassirpour Pramod P. Mehta Sangita M. Baxi Min-Jean Yin

Patients with triple-negative breast cancers (TNBCs) typically have a poor prognosis. TNBCs are characterized by their resistance to apoptosis, aggressive cellular proliferation, migration and invasion, and currently lack molecular markers and effective targeted therapy. Recently, miR-221/miR-222 have been shown to regulate ERα expression and ERα-mediated signaling in luminal breast cancer cell...

2014
Zsuzsanna Suba

Epidemiologic studies strongly support that triple-negative breast cancers (TNBCs) may be distinct entities as compared with estrogen receptor (ER)+ tumors, suggesting that the etiologic factors, clinical characteristics, and therapeutic possibilities may vary by molecular subtypes. Many investigations propose that reproductive factors and exogenous hormone use differently or even quite inverse...

2014
Jose Villacorta Hidalgo Peter Bronsert Marzenna Orlowska-Volk Liliana B. Díaz Elmar Stickeler Martin Werner Annette Schmitt-Graeff Gian Kayser Miroslav Malkovsky Paul Fisch

Breast cancer is the leading cause of cancer death in women and the second most common cancer worldwide after lung cancer. The remarkable heterogeneity of breast cancers influences numerous diagnostic, therapeutic, and prognostic factors. Triple-negative breast carcinomas (TNBCs) lack expression of HER2 and the estrogen and progesterone receptors and often contain lymphocytic infiltrates. Most ...

2018
Ga Young Yoon Joo Hee Cha Hak Hee Kim Hee Jung Shin Eun Young Chae Woo Jung Choi

PURPOSE Our study investigated whether any sonographic findings could be useful for differentiating between small triple-negative breast cancer (TNBC) and fibroadenoma. METHODS This retrospective study was approved by our Institutional Review Board, which waived the requirement for patient consent. From January 2009 to December 2010, the sonographic features of 181 pathologically proven TNBC ...

2017
Angela Ogden Chakravarthy Garlapati Xiaoxian (Bill) Li Ravi Chakra Turaga Gabriela Oprea-Ilies Nikita Wright Shristi Bhattarai Karuna Mittal Ceyda Sönmez Wetherilt Uma Krishnamurti Michelle D. Reid Mildred Jones Meenakshi Gupta Remus Osan Sonal Pattni Ansa Riaz Sergey Klimov Arundhati Rao Guilherme Cantuaria Padmashree C. G. Rida Ritu Aneja

Nuclear KIFC1 (nKIFC1) predicts worse outcomes in breast cancer, but its prognostic value within racially distinct triple-negative breast cancer (TNBC) patients is unknown. Thus, nKIFC1 expression was assessed by immunohistochemistry in 163 African American (AA) and 144 White TNBC tissue microarrays (TMAs) pooled from four hospitals. nKIFC1 correlated significantly with Ki67 in White TNBCs but ...

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