autoimmune polyglandular syndrome (aps) type 2 is characterized by the presence of addison's disease, in association with autoimmune thyroid disease and/or type 1 diabetes mellitus. aps type 2 occurs most often in middle aged females and is rare in children. here an 11 year old boy is reported with addison's disease who developed symptom's of diabetes mellitus, goiter, malabsorption, macrocytic...

introduction: endothelium and smooth muscle dysfunction are the most important complications of diabetes. in type 1 diabetic patients, absence of insulin leads to vasoconstriction and lower skin blood perfusion. release of some mediators by endothelium which is induced by insulin causes vasodilation, but the exact mechanism of insulin vasodilatory effect is not detected properly. at present stu...

BACKGROUND Previous studies carried out in our laboratories have demonstrated impaired drug permeation in diabetic animals. In this study the permeation of diazepam (after a single dose of 5 mg/day, administered intramuscularly) will be investigated in diabetic and hypertensive pregnant women. METHODS A total 75 pregnant women were divided into three groups: group 1 (healthy control, n = 31),...

1 Glibenclamide is a widely used sulphonylurea for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). This agent has been reported to inhibit the activities of various ion channels and transporters. In the present study, we examined the effects of glibenclamide on the function of the H+/peptide cotransporters PEPT1 and PEPT2 by using stable transfectants. 2 Uptake of [14C]-glycyl...

background: recent studies have shown the immunomodulatory effect of vitamin d3 through down-regulation of toll-like receptor (tlr) expression in human monocytes. in this study, the effects of vitamin d treatment on tlr2 and tlr4 expression on monocytes derived from type 2 diabetes was investigated. materials and methods: to assess the influence of vitamin d3 on expression of tlr2 and tlr4 on m...

PURPOSE The purpose of this study was to investigate the effects of the hydro-alcoholic extract of Rhus coriaria seeds on the reproductive system of nicotinamide-streptozotocin-induced type-2 diabetic mice. MATERIALS AND METHODS In this experimental study, 56 male Naval Medical Research Institute mice were randomly divided into seven groups (n=8): control; diabetic mice; diabetic mice adminis...

Abstract: Background: Trigonella foenum-graecum L (Fenugreek) is an annual herb, mainly cultivated for its seed as well sprouts. Pharmacological investigations reported anti-bacterial, anti-diabetic, anti-cancer, anti-diarrheal, anti-hypercholesteremic, and antiinflammatory activities of L. Aim: The purpose this study was to accentuate on formulation granules investigate the effect germinated (...

Metformin and glibenclamide may have beneficial effects on the levels of trace elements in diabetic patients. The aim current study was to assess metformin concentrations copper (Cu), zinc (Zn) magnesium (Mg) patients with type 2 diabetes mellitus. metformin-treated showed significantly lower serum Cu compared untreated groups. In addition, treatment associated a significant increase Zn newly d...

Fatty liver disease is one of the most common diseases in women with type II diabetes. While regular exercise can decrease the complication of this disease, it was not clearly identified. The aim of this study was to evaluate the effect of four weeks aerobic training on Liver Transaminases and some glycemic markers in women with type II diabetes.Materials and Methods: In this study, 20 patients...