Aim: to prospectively evaluate degree of pain during transrectal ultrasound-guided prostate biopsy after receiving analgesics treatment of oral morphine sulphate compared to suppository sodium diclofenac. Methods: the study group comprised 60 consecutive men subjects (median age 67.8 years) undergoing transrectal prostate biopsy. They were randomized into two groups; group 1 received oral analg...

BACKGROUND The unimodal approach of using pentazocine as post-cesarean section pain relief is inadequate, hence the need for a safer, easily available and more effective multimodal approach. AIM To evaluate the effectiveness of rectal diclofenac combined with intramuscular pentazocine for postoperative pain following cesarean section. METHODS In this double blind clinical trial, 130 pregnan...

objective: the aim of this study is to further compare the efficacy of pge2 suppository, the intracervical foley catheter and extra-amniotic saline infusion in nulliparous women referred for labor induction. materials and methods: totally 368 nulliparous women with a bishop score ≤ 4 with singleton gestation, vertex presentation and intact membrane referred for labor induction were randomly ass...

Data from sustained-release and enteric-coated oral formulations, and the suppository formulation of diclofenac sodium are fitted simultaneously using NONMEM and the general linear model, ADVAN 5. Absorption and disposition parameters, serum levels, and absorption profiles were determined. The in vivo absorption profiles were determined using the program TOPFIT. The in vivo absorption for the s...

© 2010 The Authors. doi: 10.2340/00015555-0782 Journal Compilation © 2010 Acta Dermato-Venereologica. ISSN 0001-5555 Sir, Medicaments containing various botanical extracts (e.g. tea tree oil, aloe, calendula, Echinacea, propolis) with purported therapeutic benefits are used widely by patients, who often prefer alternative medicine to traditional topical and systemic pharmacological treatments. ...

Ph.Eur. and BP have introduced a dissolution apparatus for suppositories. Suitability of the apparatus for quality control of paracetamol suppositories was evaluated and the effect of experimental conditions on dissolution profiles was studied. Paracetamol suppositories containing 80-500 mg of the drug, on fatty base, were obtained from four manufacturers (A, B, C, D). The diffusion cell was mo...

OBJECTIVE To determine reduction in dose of tramadol and side effects in posthysterectomy patients on addition of diclofenac on rectal suppository. STUDY DESIGN Randomized double blinded placebo controlled study. PLACE AND DURATION OF STUDY The Aga Khan University Hospital, Karachi, Pakistan, from August 2004 to January 2006. METHODOLOGY Seventy ASA I and II females, aged 20 and above, wh...