Introduction: Microbubbles are widely used as contrast agent in diagnostic ultrasound. Recently they have shown good potential for applications in the therapeutic field such as drug delivery to the brain. Recent studies have shown focused ultrasound in conjunction with injected micro-bubbles could temporarily disrupt blood-brain barrier and let therapeutic agents transport into...

Using finite element nonlinear analysis, the dynamic soil pressure on perimeter retainingwalls of structures is investigated. Nonlinear Drucker Prager failure criterion is used to model the soilbehavior in the near field. The far field soil and the middle structure are assumed to behave as linearelastic materials. The soil-wall interface behavior is modeled incorporating nonlinear interfaceelem...

Specific treatment of age-related aortic wall arteriosclerosis and stiffening is lacking. Because ligands for peroxisome proliferator-activated receptor gamma have beneficial effects on the arterial wall in atherosclerosis, via an antiinflammatory mechanism, we investigated whether long-term pioglitazone (Pio) treatment protects against another form of vascular wall disease, arteriosclerosis. W...

An effort is made to evaluate the formulation of seismic active earth pressure behind a nonvertical retaining wall supporting c-Ф backfill. The formulation is prepared to get a single critical wedge surface for simultaneous action of weight, surcharge, cohesion and adhesion. The success of any retaining structure involves the awareness of seismic active earth pressure. The effect of various par...

Specific treatment of age-related aortic wall arteriosclerosis and stiffening is lacking. Because ligands for peroxisome proliferator–activated receptor have beneficial effects on the arterial wall in atherosclerosis, via an antiinflammatory mechanism, we investigated whether long-term pioglitazone (Pio) treatment protects against another form of vascular wall disease, arteriosclerosis. We eval...

At high altitudes, the air pressure is much lower than it is at sea level and contains fewer oxygen molecules and less oxygen is taken in at each breath. This requires deeper and rapid breathing to get the same amount of oxygen into the blood stream compared to breathing in air at sea level. Exercises increase the oxygen demand and make breathing more difficult at high altitude. In this study, ...

Arterial drug concentration distribution determines local toxicity. The safety issues dealt with Drug-Eluting Stents (DESs) reveal the needs for investigation about the effective factors contributing to fluctuations in arterial drug uptake. The current study focused on the importance of hypertension as an important and controversial risk factor among researchers on the efficacy of Heparin-Eluti...