The mechanism of oxidation by O2 of (dpms)Pt(II)Me(OH2) (1) and (dpms)Pt(II)Me(OH)(-) (2) [dpms = di(2-pyridyl)methanesulfonate] in water in the pH range of 4-14 at 21 °C was explored using kinetic and isotopic labeling experiments. At pH ≤ 8, the reaction leads to a C1-symmetric monomethyl Pt(IV) complex (dpms)Pt(IV)Me(OH)2 (5) with high selectivity ≥97%; the reaction rate is first-order in [P...

Central catecholaminergic (CAergic) neurones, in particular areas C1 and A2, are associated with blood pressure regulation. Links between their activity and central sympathetic outflow have been documented. Since sympathetic drive is elevated in essential hypertension, both in human patients and spontaneously hypertensive rats (SHR), hyperactive central CAergic transmission may be an underlying...

IMPORTANCE The American Joint Committee on Cancer (AJCC) has proposed the inclusion of pretreatment serum carcinoembryonic antigen (CEA) levels (C stage) into the conventional TNM staging system of colon cancer. The latter proposal has yet to be widely adopted because of the lack of long-term survival estimates of after C-stage incorporation into AJCC staging. OBJECTIVES To evaluate whether l...

A brief review of the available experimental and theoretical results on production $\chi_{Q1}$ states in $e^+e^-$ annihilation photon-photon $\gamma\gamma^*$ interactions is presented. Future data $\chi_{c1}(1P)$, $\chi_{c1}(3872)$, $\chi_{c1} (4140)$, $\chi_{c1}(4274)$, $\chi_{c1}(4685)$, $\chi_{b1} (1P)$, $\chi_{b1}(2P )$, $\chi_{b1}(3P)$ resonances will help development unification predictio...

the sporozoites of theileria annulata invade bovine mhc ii cells, where they differentiate into schizonts. the later can immortalize and induce fundamental changes in their host cells. live attenuated vaccine is an important way of controlling t. annulata infection of cattle. production is by prolonged cultivation of macroschizont-infected cells. the mechanisms underlying this transformation ar...

In this study, the catalytic use of [Pd(L1)2]Cl2 complex is aimed for reduction / degradation reactions organic pollutants in water sources which pose a threat to environment. For purpose, 2-(thiophen-2-yl)-1H-benzimidazole ligand (L1) and its Pd(II) (C1) were synthesized characterized by FT-IR, 1H-NMR, 13C-NMR, ESI-MS spectroscopic techniques. The efficiency C1 on 4-nitro phenol compound (4-NP...

We develop candidate HIV-1 vaccines, of which two components, ChAdOx1.tHIVconsv1 (C1) and ChAdOx1.HIVconsv62 (C62), are delivered by the simian adenovirus-derived vaccine vector ChAdOx1. Aberrant adenovirus RNA splicing involving transgene(s) coding for SARS-CoV-2 spike was suggested as an aetiology rare adverse events temporarily associated with initial deployment adenovirus-vectored vaccines ...

Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) is a transcription factor which regulates the expression of many cytoprotective genes. In the present study, we found that the expression of Nrf2 was suppressed in prostate tumor of the Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice. Similarly, the expression of Nrf2 and the induction of NQO1 were also substantially suppressed in ...