Two suppressor mutations of the temperature-sensitive DNA primase mutant dnaG2903 have been characterized. The gene responsible for suppression, era, encodes an essential GTPase of Escherichia coli. One mutation, rnc-15, is an insertion of an IS1 element within the leader region of the rnc operon and causes a polar defect on the downstream genes of the operon. A previously described polar mutat...

امروزه ورود به حوزه مدیریت کیفیت برای سازمان‌ها از اهمیت ویژه‌­ای برخوردار است. مدل­های تعالی سازمانی ابزاری است که را در این مسیر رهنمون می­‌کند. بدین منظور، ازجمله شبکه بانکی کشور، رویکردهای گوناگونی سازمان خود راستای تحقق ارزش‌های مدل­‌های استقرار می­کنند؛ اما محدودیت منابع موجود قبیل هزینه، نیروی انسانی، فرهنگ و غیره، تمامی رویکردها میسر نمی‌­سازد؛ ازاین‌رو مسئله اصلی کدام بیشترین تأثیر ارت...

کاهش هزینه‏‌های مرتبط با موجودی از مهم‌ترین استراتژی‌‏های هر بنگاه اقتصادی برای بقا و سوددهی در شرایط رقابتی امروزی است. این راستا مدل‏‌های کلاسیک هزینه‏‌ها مطرح شده‌اند؛ اما کنار مزایای فراوان دارای فرضیه‌های محدودکننده‌ای هستند. پژوهش، یک زنجیره سه­‌سطحی لجستیکی شامل تولیدکننده، توزیع‌‏کننده خرده‏‌فروش نظر گرفته می‏‌شود مسئله بهینه‌سازی مدل توزیع‌کننده موردبررسی قرار می‏‌گیرد. موردنظر، توزیع‏...

Resistance to hormonal therapies is a major clinical problem in the treatment of estrogen receptor a–positive (ERaþ) breast cancers. Epigenetic marks, namely DNA methylation of cytosine at specific CpG sites (5mCpG), are frequently associated with ERaþ status in human breast cancers. Therefore, ERa may regulate gene expression in part via DNA methylation. This hypothesis was evaluated using a p...

According to the life cycle model of technological evolution, after the emergence of a dominant design, technological product industries undergo an “era of incremental change.” This era of incremental change is not well understood in the existing literature. Although the period is typically characterized in terms of stability and minimal innovation, we find that the era of incremental change ca...

ندارد

the abbasid era has been the period of florescence of the islamic culture and civilization. literature was of great contention in this era.the present article studies the relationship between translation and literary criticism which resulted in changes in the basic theories of literary criticism by critics.

timur began his domination by the help he received from parts of the chaghataid troops. then and concurrent to extending his realm and power, he recruited defeated populations as new part of his army. simultaneously he established household – provincial powers in his occupations which his sons and grandsons ruled over them. this political – administrative tradition was followed by his successor...

CONTEXT Presently the MELD score is used as the waiting list criterion for liver transplantation in Brazil. In this method more critical patients are considered priority to transplantation. OBJECTIVE To compare the results of liver transplantation when the chronologic waiting list was the criterion for organ allocation (pre-MELD era) with MELD score period (MELD era) in one liver transplantat...