A KEY FACET of ‘‘More than Moore’’ scaling comes under the heading of ‘‘3D’’ the stacking of multiple integrated-circuit dies using through-silicon vias (TSVs). Stacked-die products reached the marketplace decades ago, but with peripheral I/O on individual dies and interchip interconnect on the ‘‘side’’ of the stack. TSVs are a game changer, with diameters and pitches that permit thousands of t...

Human interferon alpha (hIFNα) is a wide biological activity cytokine that is used in hepatitis and cancer treatments. It regulates many genes that are involved in antiviral and antiproliferative activities. This mini review focuses on human interferon alpha-2b (hIFNα-2b) as therapeutic protein for cancer treatment. The review covers hIFNα-2b molecular characteristic and its molecular mechanism...

ackground: knowing the human platelet antigens (hpa) and genes frequency in different populations is important not only for population studies but also for clinical transfusion practice. hpa genes frequency in iran is not evaluated, so we investigated the hpa-2, hpa-3, and hpa-5 frequency and their polymorphism. materials and methods: dna from 120 iranians (99 iranian blood donors and 21 patien...

Mucosal neuromas are a form of neurogenic tumour that arises in the oral cavity as a component of multiple endocrine neoplasia type 2b (MEN 2b). The syndrome is characterized with other features like tumors of the endocrine glands and skeletal abnormalities. Mutation at codon 918 of the RET protooncogene is a consistent feature among people affected with MEN 2. There are few reports describing ...

Protein purification and molecular cloning have defined five classes of protein serine-threonine phosphatase catalytic subunits referred to as types 1, 2A, 2B (calcineurin), 2C, and X. Protein serine-threonine phosphatases 1, 2A, 2B, and X appear to have significant sequence homologies, whereas the 2C enzyme is more divergent. We have used the polymerase chain reaction to define the multiplicit...

Two different families of hydroxyproline-rich glycoproteins, HRGP(1) and HRGP(2), have been isolated from melon callus and separated by ion exchange chromatography on CM-sepharose. HRGP(1) corresponds to an arabinogalactan protein. The sugar portion of HRGP(1) accounts for 94% of the molecule and contains galactose (66%) and arabinose (34%); these residues are present as polysaccharide side cha...

Learning and memory depend on morphological and functional changes to neural spines. Non-muscle myosin 2b regulates actin dynamics downstream of long-term potentiation induction. However, the mechanism by which myosin 2b is regulated in the spine has not been fully elucidated. Here, we show that filamin A-interacting protein (FILIP) is involved in the control of neural spine morphology and is l...