The response of atmospheric CO2 and climate to the reconstructed variability in solar irradiance and radiative forcing by volcanoes over the last millennium is examined by applying a coupled physical-biogeochemical climate model that includes the Lund-Potsdam-Jena dynamic global vegetation model (LPJ-DGVM) and a simplified analogue of a coupled atmosphere-ocean general circulation model. The mo...

BACKGROUND Chronic pain causes a significant burden to the US health care system, is difficult to treat, and remains a significant contributor to increased opioid use in the United States. Spinal cord stimulation (SCS) has been FDA approved for the treatment of chronic pain. OBJECTIVE To evaluate the hypothesis that SCS reduces opioid use, and alone maintains clinical outcome measures of pain...

BACKGROUND/AIMS Nonsteroidal anti-inflammatory drugs relieve osteoarthritis (OA) symptoms but cause adverse effects. D-002, a mixture of beeswax alcohols, is effective against experimental OA. A pilot study found that D-002 (50 mg/day) for 8 weeks improves OA symptoms. The aim of this study was to investigate the effects of D-002 (50 to 100 mg/day) administered for 6 weeks on OA symptoms. MET...

CONTEXT Nosocomial infections are an important cause of morbidity and mortality after cardiac surgery. Decolonization of endogenous potential pathogenic microorganisms is important in the prevention of nosocomial infections. OBJECTIVE To determine the efficacy of perioperative decontamination of the nasopharynx and oropharynx with 0.12% chlorhexidine gluconate for reduction of nosocomial infe...

SOLUBLE ST2 BLOCKS IL-33 SIGNALING IN ALLERGIC AIRWAY INFLAMMATION Hiroko Hayakawa1, Morisada Hayakawa1, Akihiro Kume2, and Shin-ichi Tominaga1 From the 1Department of Biochemistry and 2Division of Genetic Therapeutics, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan Running Title: Suppression of IL-33 signaling by soluble ST2 Address correspondence to: Moris...

In an ongoing survey of Korean indigenous fungi, three fungal strains belonging to the Sordariomycetes were isolated from soil samples. These strains were designated KNU16-001, KNU16-002, and KNU16-009, and identified as Ambrosiella grosmanniae, Acremonium sclerotigenum, and Trichocladium asperum, respectively, based on morphological characterization and phylogenetic analysis using internal tra...