Human glioblastoma is a highly lethal tumor that is known for its immune inhibitory capabilities. B7-homologue 1 (B7-H1), a recently identified homologue of B7.1/2 (CD80/86), has been described to exert costimulatory and immune regulatory functions. We investigated the expression and the functional activity of B7-H1 in human glioma cells in vitro and in vivo. Although lacking B7.1/2 (CD80/86), ...

The aim of the present study was to determine the preliminary mechanism of action of B7 homolog 1 (B7-H1) and investigate the association between B7-H1 and cervical cancer. The expression of B7 family proteins was measured in cervical cancer cells. Cervical cancer cells were co-cultured with T lymphocytes. An ELISA assay was subsequently conducted to analyze cytokine concentrations in the super...

1 Parameter estimation Since we cannot observe the hidden variablesH1:T , we cannot solve the parameter estimation problem by simply counting events from a dataset. Instead we must apply some method that can give us an approximate solution. The canonical way of parameter estimation in HMM is to use EM, and therefore we shall also adopt this technique for our GBN-HMMs. As before, let o1:T repres...

When whole steer kidney nuclei were treated with dimethyl-3,3'-dithiobisproprionimidate, N,N'-bis(2-carboxyimidomethyl) tartaramide dimethyl ester, or 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide under approximately physiological ionic conditions, H1 histone was cross-linked to each of the four histones in the nucleosome core. The carbodiimide reagent, which introduces no atoms between the am...

In this paper we prove that the spherical subalgebra eH1,τ e of the double affine Hecke algebra H1,τ is an integral Cohen-Macaulay algebra isomorphic to the center Z of H1,τ , and H1,τ e is a Cohen-Macaulay eH1,τ emodule with the property H1,τ = EndeH1,τ e(H1,τ e) when τ is not a root of unity. In the case of the root system An−1 the variety Spec(Z) is smooth and coincides with the completion o...

The interaction of the non-histone chromosomal protein HMG (high-mobility group) 1 with histone H1 subfractions was investigated by equilibrium sedimentation and n.m.r. sectroscopy. In contrast with a previous report [Smerdon & Isenberg (1976) Biochemistry 15, 4242--4247], it was found, by using equilibrium-sedimentation analysis, that protein HMG 1 binds to all three histone H1 subfractions CT...

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Given bipartite graphs H1 and H2, the bipartite Ramsey number b(H1;H2) is the smallest integer b such that any subgraph G of the complete bipartite graph Kb,b, either G contains a copy of H1 or its complement relative to Kb,b contains a copy of H2. It is known that b(K2,2;K2,2) = 5, b(K2,3;K2,3) = 9, b(K2,4;K2,4) = 14 and b(K3,3;K3,3) = 17. In this paper we study the case H1 being even cycles a...

Lipoxygenases catalyze the formation of fatty acid hydroperoxide precursors of an array of compounds involved in the regulation of plant development and responses to stress. To elucidate the function of the potato 13-lipoxygenase H1 (LOX H1), we have generated transgenic potato plants with reduced expression of the LOX H1 gene as a consequence of co-suppression-mediated gene silencing. Three in...