نتایج جستجو برای: a2a receptors
تعداد نتایج: 225580 فیلتر نتایج به سال:
Cocaine addiction is a brain disorder that affects millions of people and generates enormous social and economic costs to society. The continuous potential for relapse during periods of withdrawal makes treatment of cocaine addiction especially difficult. These studies investigate the molecular mechanisms mediating relapse behavior in a rodent model of cocaine addiction. Recent studies have dem...
OBJECTIVES For determining the mechanism of anti-asthmatic effect of thymoquinone, this investigation evaluated the effect of thymoquinone in the presence of selective A2A and A2B adenosine receptor antagonists (ZM241385 and MRS1706, respectively). MATERIALS AND METHODS Seventy guinea pigs were randomly divided to 7 groups; control (C), sensitized with ovalbumin (S), sensitized groups pretrea...
Agonist binding to extracellular A2A adenosine receptors (A2ARs) inhibits the activation of virtually all tested functions of T-cells and can induce apoptosis in thymocytes. The evaluation of levels of expression of these immunosuppressive receptors is expected to clarify whether the absence of spare A2ARs (no 'receptor reserve') might be one of the mechanisms of attenuation of the effects of e...
P2Y(12) receptor antagonists are antithrombotic agents that inhibit platelet function by blocking the effects of adenosine diphosphate (ADP) at P2Y (12)receptors. However, some P2Y(12) receptor antagonists may affect platelet function through additional mechanisms. It was the objective of this study to investigate the possibility that P2Y(12) antagonists inhibit platelet function through intera...
Background: Parkinson's disease is an attractive model to extend research towards a better understanding of the interrelationship between genes and environment (exposome) therefore ideal for polypharmacological approach due its clinical heterogeneity. Methods: In this paper, we present series chemical scaffolds extracted from ChEMB...
Few studies to date have looked at the effects of caffeine on synaptic plasticity, and those that did used very high concentrations of caffeine, whereas the brain concentrations attained by regular coffee consumption in humans should be in the low micromolar range, where caffeine exerts pharmacological actions mainly by antagonizing adenosine receptors. Accordingly, rats drinking caffeine (1 g/...
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