Sleep has been hypothesised to maintain a close relationship with metabolism. Here we focus on the brain structure that triggers slow-wave sleep, the ventrolateral preoptic nucleus (VLPO), to explore the cellular and molecular signalling pathways recruited by an increase in glucose concentration. We used infrared videomicroscopy on ex vivo brain slices to establish that glucose induces vasodila...

The ecto-5′-nucleotidase CD73 is involved in the production of immunosuppressive adenosine tumoral microenvironment and recently became a validated target immuno-oncology. To avoid formation CD73-produced adenosine, several series potential inhibitors enzyme based on triazole scaffold were synthetized evaluated recombinant purified hCD73 cell-based assays.

Adenosine, acting both through G-protein coupled adenosine receptors and intracellularly, plays a complex role in multiple physiological pathophysiological processes by modulating neuronal plasticity, astrocytic activity, learning memory, motor function, feeding, control of sleep aging. Adenosine is involved stroke, epilepsy neurodegenerative pathologies. Extracellular concentration the brain t...

Introduction: Tuberculous pleurisy is one of the most common form of extrapulmonary tuberculosis (TB). Measurement of adenosine deaminase (ADA) level in the effusions is advocated to have a high diagnostic yield in the diagnosis of tuberculous pleurisy as well as pericardial and peritoneal effusions due to TB. The diagnostic yield of ADA measurement in other materials such as abscess content ha...

Xu, Fenglian, Jianhua Xu, Frederick W. Tse, and Amy Tse. Adenosine stimulates depolarization and rise in cytoplasmic [Ca ] in type I cells of rat carotid bodies. Am J Physiol Cell Physiol 290: C1592–C1598, 2006. First published January 25, 2006; doi:10.1152/ajpcell.00546.2005.—During hypoxia, the level of adenosine in the carotid bodies increases as a result of ATP catabolism and adenosine effl...

BACKGROUND In some studies, the level of adenosine deaminase (ADA) in sputum and effusion liquids was used for the diagnosis of tuberculosis (TB). But it is not always possible to access these materials. The goal of this study is to assess the diagnostic value of serum ADA levels in pulmonary TB patients. MATERIALS AND METHODS In this study, 40 sputum smear-positive TB patients who were hospi...

BACKGROUND We investigated the incidence of tuberculous pleurisy among patients with adenosine deaminase (ADA) levels of 50 IU/L or less in a pleural effusion, and without a previous diagnosis of carcinomatous pleurisy or Mycobacterium tuberculosis. SUBJECTS AND METHODS Subjects were selected from patients who had undergone pleural biopsy by thoracoscopy at National Hospital Organization Toky...

theophylline tablet. J Clin Pharmacol 1982; 22:196-200 3 Osman MA, Patel RB, Irwin DS, Welling PG. Absorption of theophylline from enteric coated and sustained-release furmulations in fasted and non-fasted subject. Biopharm Drug Disposition 1983; 4:63-72 4 Pedersen S, Moller-Petersen J. Erratic absorption of a slowrelease theophylline sprinkle product. Pediatrics 1984; 74:534-38 5 Jonkman HJC, ...

Adenosine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Receptors [112]) are activated endogenous ligand adenosine (potentially inosine also at A3 receptors). Crystal structures for antagonist-bound [155, 316, 224, 62], agonist-bound [379, 205, 206] and G protein-bound A2A [49] have been described. The of an A1 receptor [130] adenosine-bound receptor-Gi complex [87] resolve...

adenosine deaminase is an aminohydrolase (ec 3.5.4.4) which participates in the purine metabolism where it degrades either adenosine or 2'-deoxyadenosine producing inosine or 2'-deoxyinosine, respectively. the enzyme contains a parallel alpha/beta -barrel motif with eight central beta strands and eight peripheral alpha helices. ada is located both in the cytosol and on the cell membrane. since ...