Serum albumin is the major determinant of blood colloidal osmotic pressure acting as a depot and distributor of compounds including drugs. In humans, serum albumin exhibits an unusually long half-life mainly due to protection from catabolism by neonatal Fc receptor (FcRn)-mediated recycling. These properties make albumin an attractive courier of therapeutically-active compounds. However, pharma...

Objective(s): Cancer diagnosis in its early stages of progress, can enhance the efficiency of treatment utilizing conventional therapy methods. Non-biocompatibility of iron oxide nanoparticles (IONPs) has made a big challenge against their usage as a contrast agent. Efficient coverage by biomolecules such as albumin can be a solution to overcome this problem. Herein, albumin-coated IONPs were p...

background: receptor for advanced glycation end products (rage) plays a causative role in diabetes. garlic (allium sativum) belongs to compounds with anti-glycation activity that can be considered as probable therapeutic approaches in delaying or preventing the onset of diabetes complications. the aim of this study was to evaluate the influence of garlic on the rage expression and proinflammato...

background: obesity is caused by several factors while sedentary lifestyle and excessive energy intake are the most important ones. obesity could be due to abnormal calcium metabolism, and a high calcium intake may prevent obesity. studying serum calcium level, albumin, and triglyceride concentrations, we searched for probable correlation between serum calcium level and anthropometric data of t...

CLINICALCHEMISTRY, Vol. 34, No. 2, 1988 461 3. Huber C, Batchelor JR, Fuchs D, et al. Immune response-associatedproduction of neopterin-release from macrophages primanly under control of interferon-gamma. J Exp Med 1984;160:310-6. 4. Nathan CF. Peroxide and pteridine: a hypothesis onthe regulationof macrophage antimicrobial activity by interferon-gainma. In: Greaser I, Vilcek J, eds.Interferon,...

Introduction: Community-acquired pneumonia (CAP) is a common type of respiratory tract infections with high morbidity and mortality. Prognostic role CRP/Albumin ratio in CAP patients still unknown. The aim this study was to investigate the CRP/albumin predicting 30-day mortality ICU requirement hospitalized CAP.
 Material Method: included CAP.Clinical records plain radiographic images were...

background and aims: in this lab trial, the effect of scaffold based on human serum albumin (hsa) and hydroxyapatite nanoparticles (ha nps) on mouse spermatogonial cell line (scl) was investigated. materials and methods: to synthesize ha nps, calcium nitrate and diammonium phosphate at ph 13 were gently added and heated at 100 ºc for 24 hours. then serial concentrations of ha nps was separately...