نتایج جستجو برای: antitoxins
تعداد نتایج: 1240 فیلتر نتایج به سال:
SUMMARY A diphtheria outbreak occurred from February to November 2011 in the village of Kimba and its surrounding settlements, in Borno State, northeastern Nigeria. We conducted a retrospective outbreak investigation in Kimba village and the surrounding settlements to better describe the extent and clinical characteristics of this outbreak. Ninety-eight cases met the criteria of the case defini...
Botulism is a serious disease caused by botulinum toxin produced by the Clostridium botulinum, an anaerobic, gram positive, spore forming bacillus which exists in environment. In this article, we describe the foodborne botulism due to consumption of locally made cheese in two members of a family. Patients attended a clinical center with myasthenia, ptosis and dysphagia. The preliminary diagnosi...
AAU-Specific RNA Cleavage Mediated by MazF Toxin Endoribonuclease Conserved in Nitrosomonas europaea
Nitrosomonas europaea carries numerous toxin-antitoxin systems. However, despite the abundant representation in its chromosome, studies have not surveyed the underlying molecular functions in detail, and their biological roles remain enigmatic. In the present study, we found that a chromosomally-encoded MazF family member, predicted at the locus NE1181, is a functional toxin endoribonuclease, a...
The bacterial relBE locus encodes a toxin-antitoxin complex in which the toxin, RelE, is capable of cleaving mRNA in the ribosomal A site cotranslationally. The antitoxin, RelB, both binds and inhibits RelE, and regulates transcription through operator binding and conditional cooperativity controlled by RelE. Here, we present the crystal structure of the intact Escherichia coli RelB2E2 complex ...
Certain type II restriction modification gene systems can kill host cells when these gene systems are eliminated from the host cells. Such ability to cause postsegregational killing of host cells is the feature of bacterial addiction modules, each of which consists of toxin and antitoxin genes. With these addiction modules, the differential stability of toxin and antitoxin molecules in cells pl...
Attis and SoilAssassin are two closely related bacteriophages isolated on Gordonia terrae 3612 from separate soil samples in Pittsburgh, PA. The Attis and SoilAssassin genomes are 47,881 bp and 47,880 bp, respectively, and have 74 predicted protein-coding genes, including toxin-antitoxin systems, but no tRNAs.
tact, whereas those for a = 0.02 imply only 25% more frequent contacts than the all-ornone hypothesis but with rather high though rapidly diminishing attack rates. 10 Schuman and Doull, Amer. Jour. Pub. Health, 30, Supplement to March, 1940, p. 21, state: "From these estimates of carrier prevalence and froni the average annual increment in Shick-negatives, an estimate may be made of the number ...
The antiprotein in an antipneumococcus horse serum resulting from intravenous injections of infected pleural exudate showed a precipitin type of reaction with pneumococcus nucleoprotein rather than the antitoxin type of response.
Bacteria show remarkable adaptability under several stressful conditions by shifting themselves into a dormant state. Less is known, however, about the mechanism underlying the cell transition to dormancy. Here, we report that the transition to dormant states is mediated by one of the major toxin-antitoxin systems, RelEB, in a cell density-dependent manner in Escherichia coli K-12 MG1655. We co...
during the journey to India. I have now received specimens of the serum on two occasions, and find that they possess a well-marked power of neutralising cobra venom, the last received specimens being especially active. I do not propose on the present occasion to go into the details of my experiments. I may, however, briefly mention a semi-practical application that I have been able to make of P...
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