The intracellular reduction-oxidation (redox) environment influences cell cycle progression; however, underlying mechanisms are poorly understood. To examine potential mechanisms, the intracellular redox environment was characterized per cell cycle phase in Chinese hamster ovary fibroblasts via flow cytometry by measuring reduced glutathione (GSH), reactive oxygen species (ROS), and DNA content...

Reactive oxygen and nitrogen species (e.g. H2O2, nitric oxide) confer redox regulation of essential cellular signaling pathways such as cell differentiation, proliferation, migration and apoptosis. In addition, classical regulation of gene expression or activity, including gene transcription to RNA followed by translation to the protein level, by transcription factors (e.g. NF-κB, HIF-1α) and m...

Due to some important applications of guanine electrode in scientific and technology research such as electro-chemical DNA based biosensors, and a problem of high redox potential of guanine (0.81 V), our research study concentrates on reducing guanine redox potential by substituting Cu, Ag, Au, CH3, C2H5 and Cl on sites of 1, 2 and 9 of guanine. A 5.0% reduction...

conditioning in the isolated nervous system is attenuated in presence of the NMDA receptor antagonist APV. This finding is consistent with the results of Lin and Glanzman (1994), which indicated that the influx of calcium through NMDA receptors in the postsynaptic neu-ron is necessary for facilitation, and suggests that a Houston, Texas 77030 Hebbian mechanism is important for classical conditi...

Recently different approaches have been developed in the field of sensor fault diagnostics based on Auto-Associative Neural Network (AANN). In this paper we present a novel algorithm called Self reconstructing Auto-Associative Neural Network (S-AANN) which is able to detect and isolate single faulty sensor via reconstruction. We have also extended the algorithm to be applicable in multiple faul...

Let R be an associative ring with identity, C(R) be the category of com-plexes of R-modules and Flat(C(R)) be the class of all at complexes of R-modules. We show that the at cotorsion theory (Flat(C(R)); Flat(C(R))−)have enough injectives in C(R). As an application, we prove that for each atcomplex F and each complex Y of R-modules, Exti (F,X)= 0, whenever Ris n-perfect and i > n.

Oridonin, the main active constituent of Rabdosia rubescens, is known to exert antitumor activity via the induction of apoptosis in numerous types of human cancer cells. However, the underlying regulatory mechanisms of mitochondrial ROS in oridonin-induced HepG2 apoptosis remain largely unknown, due to limitations of subcellular imaging resolution. Previously, it has been suggested that mitocho...

Lipid rafts, the sphingolipid and cholesterol-enriched membrane microdomains, are able to form different membrane macrodomains or platforms upon stimulations, including redox signaling platforms, which serve as a critical signaling mechanism to mediate or regulate cellular activities or functions. In particular, this raft platform formation provides an important driving force for the assembling...

One of the important and necessary practices for improving nutrients availability in sustainable agriculture is using microorganisms. Beside the negative effects of chemical fertilizers on the soil and human health, plant growth promoting rhizobacteria are known as an alternative to supply the organic nutrients of plants during the past two decades. Enriching soil fertility by eco-friendly meth...