The intermolecular interaction of the benzene-water complex is calculated using real-space pseudopotential density functional theory utilizing a van der Waals density functional. Our results for the intermolecular potential energy surface clearly show a stable configuration with the water molecule standing above or below the benzene with one or both of the H atoms pointing toward the benzene pl...

Ethanol is known to exert a synergistic effect on the toxicity of benzene. In the present investigation it was found that benzene was metabolized at a rate 20-65-fold higher in liver microsomes from ethanolor acetonetreated rats than in microsomes from control animals. One high affinity site \Ka = 19 ±5 (SD) urn] and one low affinity site [K„ = 0.3 ±0.1 IIIM| for benzene metabolism were pre...

Objectives—To evaluate the contribution of traYc fumes to exposure to benzene in urban workers, an investigation on personal exposure to benzene in traYc police from the city of Rome was carried out. Methods—The study was performed from December 1998 to June 1999. DiVusive Radiello personal samplers were used to measure external exposures to benzene and alkyl benzenes during the workshift in 13...

We studied the in vivo metabolism of benzene in mice to ring-opened compounds excreted in urine. Male CD-1 mice were treated intraperitoneally with benzene (110-440 mg/kg), [14C]benzene (220 mg/kg) or trans, trans-muconaldehyde (MUC; 4 mg/kg), a microsomal, hematotoxic metabolite of benzene. Urine, collected over 24 hr, was extracted and analyzed by HPLC with a diode-array detector and by scint...

Ethanol is known to exert a synergistic effect on the toxicity of benzene. In the present investigation it was found that benzene was metabolized at a rate 20-65-fold higher in liver microsomes from ethanol- or acetone-treated rats than in microsomes from control animals. One high affinity site [Km = 19 +/- 5 (SD) microM] and one low affinity site [Km = 0.3 +/- 0.1 mM] for benzene metabolism we...

OBJECTIVES To evaluate the contribution of traffic fumes to exposure to benzene in urban workers, an investigation on personal exposure to benzene in traffic police from the city of Rome was carried out. METHODS The study was performed from December 1998 to June 1999. Diffusive Radiello personal samplers were used to measure external exposures to benzene and alkyl benzenes during the workshif...

Near-infrared and ultraviolet absorption of water-benzene mixtures has been measured at temperatures and pressures in the ranges of 323-673 K and 50-400 bar, respectively. Concentrations of water and benzene in both the water-rich phase and the benzene-rich phase of the mixtures were obtained from absorption intensities of near-infrared bands of water and benzene and ultraviolet bands of benzen...