نتایج جستجو برای: bk channel

تعداد نتایج: 228976  

Journal: :The Journal of pharmacology and experimental therapeutics 2007
Xiao-Hui Sun Jiu-Ping Ding Hui Li Na Pan Lu Gan Xiang-Liang Yang Hui-Bi Xu

Puerarin is the main isoflavone found in Pueraria lobata (Willd) Ohwi, which has been used in therapy for various cardiovascular diseases. The present study examined the effects of puerarin on the large-conductance voltage- and Ca2+-activated potassium (BK(Ca)) channel and on rat thoracic aortas. BK(Ca) channels encoded with either alpha (BK-alpha) or alpha/beta subunits (BK-alpha+beta1) were h...

2014
Anna N. Bukiya Jacob McMillan Jianxi Liu Bangalore Shivakumar Abby L. Parrill Alex M. Dopico

Calcium/voltage-gated, large-conductance potassium (BK) channels control numerous physiological processes, including myogenic tone. BK channel regulation by direct interaction between lipid and channel protein sites has received increasing attention. Leukotrienes (LTA4,LTB4,LTC4,LTD4, LTE4) are inflammatory lipid mediators. We performed patch-clamp studies in Xenopus oocytes that co-expressed B...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2013
Pablo Miranda Jorge E Contreras Andrew J R Plested Fred J Sigworth Miguel Holmgren Teresa Giraldez

Large-conductance voltage- and calcium-dependent potassium channels (BK, "Big K+") are important controllers of cell excitability. In the BK channel, a large C-terminal intracellular region containing a "gating-ring" structure has been proposed to transduce Ca(2+) binding into channel opening. Using patch-clamp fluorometry, we have investigated the calcium and voltage dependence of conformation...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Joël Tabak Maurizio Tomaiuolo Arturo E Gonzalez-Iglesias Lorin S Milescu Richard Bertram

The electrical activity pattern of endocrine pituitary cells regulates their basal secretion level. Rat somatotrophs and lactotrophs exhibit spontaneous bursting and have high basal levels of hormone secretion, while gonadotrophs exhibit spontaneous spiking and have low basal hormone secretion. It has been proposed that the difference in electrical activity between bursting somatotrophs and spi...

2016
Qin Li Xin Guan Karen Yen Jiyuan Zhang Jiusheng Yan

The large-conductance, calcium-activated potassium (BK) channels consist of the pore-forming, voltage- and Ca(2+)-sensing α subunits (BKα) and the tissue-specific auxiliary β and γ subunits. The BK channel γ1 subunit is a leucine-rich repeat (LRR)-containing membrane protein that potently facilitates BK channel activation in many tissues and cell types through a vast shift in the voltage depend...

Journal: :The Journal of physiology 2005
Matthias E Werner Peter Zvara Andrea L Meredith Richard W Aldrich Mark T Nelson

Penile erection is dependent on the nitric oxide (NO)/cGMP-dependent protein kinase I (PKGI) pathway. One important target of PKGI in smooth muscle is the large-conductance, calcium-activated potassium (BK) channel, which upon activation hyperpolarizes the smooth muscle cell membrane, causing relaxation. Relaxation of arterial and corpus cavernosum smooth muscle (CCSM) is necessary to increase ...

Journal: :Journal of the American Society of Nephrology : JASN 2006
Matthias Sausbier Joana E Matos Ulrike Sausbier Golo Beranek Claudia Arntz Winfried Neuhuber Peter Ruth Jens Leipziger

K(+) secretion in the kidney and distal colon is a main determinant of K(+) homeostasis. This study investigated the identity of the relevant luminal secretory K(+) ion channel in distal colon. An Ussing chamber was used to measure ion transport in the recently generated BK channel-deficient (BK(-/-)) mice. BK(-/-) mice display a significant colonic epithelial phenotype with (1) lack of Ba(2+)-...

Journal: :The Journal of General Physiology 2004
Weiyan Li Richard W. Aldrich

Potassium channels have a very wide distribution of single-channel conductance, with BK type Ca(2+)-activated K(+) channels having by far the largest. Even though crystallographic views of K(+) channel pores have become available, the structural basis underlying BK channels' large conductance has not been completely understood. In this study we use intracellularly applied quaternary ammonium co...

2011
Ulrike Sausbier Christian Dullin Jeannine Missbach-Guentner Clement Kabagema Katarina Flockerzie Gerd Marten Kuscher Walter Stuehmer Winfried Neuhuber Peter Ruth Frauke Alves Matthias Sausbier

BACKGROUND The process of bone resorption by osteoclasts is regulated by Cathepsin K, the lysosomal collagenase responsible for the degradation of the organic bone matrix during bone remodeling. Recently, Cathepsin K was regarded as a potential target for therapeutic intervention of osteoporosis. However, mechanisms leading to osteopenia, which is much more common in young female population and...

Journal: :Circulation research 2007
Mary K McGahon Durga P Dash Aruna Arora Noreen Wall Jennine Dawicki David A Simpson C Norman Scholfield J Graham McGeown Tim M Curtis

Retinal vasoconstriction and reduced retinal blood flow precede the onset of diabetic retinopathy. The pathophysiological mechanisms that underlie increased retinal arteriolar tone during diabetes remain unclear. Normally, local Ca(2+) release events (Ca(2+)-sparks), trigger the activation of large-conductance Ca(2+)-activated K(+)(BK)-channels which hyperpolarize and relax vascular smooth musc...

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