نتایج جستجو برای: bk channel

تعداد نتایج: 228976  

Journal: :American journal of physiology. Cell physiology 2011
Kiril L Hristov Muyan Chen Whitney F Kellett Eric S Rovner Georgi V Petkov

The large-conductance voltage- and Ca(2+)-activated K(+) (BK) channel is expressed in many smooth muscle types, but its role in human detrusor smooth muscle (DSM) is unclear. With a multidisciplinary approach spanning channel molecules, single-channel activity, freshly isolated human DSM cells, intact DSM preparations, and the BK channel specific inhibitor iberiotoxin, we elucidated human DSM B...

2011
Jie Tao Jian Shi Li Yan Ying Chen Yan Hong Duan Pin Ye Qi Feng Jian Wei Zhang Xue Qin Shu Yong Hua Ji

BACKGROUND BK channels are usually activated by membrane depolarization and cytoplasmic Ca(2+). Especially,the activity of BK channel (α+β4) can be modulated by martentoxin, a 37 residues peptide, with Ca(2+)-dependent manner. gBK channel (glioma BK channel) and BK channel (α+β1) possessed higher Ca(2+) sensitivity than other known BK channel subtypes. METHODOLOGY AND PRINCIPAL FINDINGS The p...

Journal: :Circulation research 2010
Tong Lu Dai-Min Zhang Xiao-Li Wang Tongrong He Ru-Xing Wang Qiang Chai Zvonimir S Katusic Hon-Chi Lee

RATIONALE The large conductance Ca(2+)-activated K(+) (BK) channel, a key determinant of vascular tone, is regulated by angiotensin II (Ang II) type 1 receptor signaling. Upregulation of Ang II functions and downregulation of BK channel activities have been reported in diabetic vessels. However, the molecular mechanisms underlying Ang II-mediated BK channel modulation, especially in diabetes me...

2014
Hui Xu Hannah Garver Roxanne Fernandes James J. Galligan Gregory D. Fink

Xu H, Garver H, Fernandes R, Galligan JJ, Fink GD. Altered L-type Ca channel activity contributes to exacerbated hypoperfusion and mortality in smooth muscle cell BK channel-deficient septic mice. Am J Physiol Regul Integr Comp Physiol 307: R138–R148, 2014. First published May 14, 2014; doi:10.1152/ajpregu.00117.2014.—We determined the contribution of vascular large conductance Ca -activated K ...

Journal: :American journal of physiology. Cell physiology 2014
Zohreh Hosseinzadeh Ahmad Almilaji Sabina Honisch Tatsiana Pakladok GuoXing Liu Shefalee K Bhavsar Peter Ruth Ekaterina Shumilina Florian Lang

The iberiotoxin-sensitive large conductance voltage- and Ca(2+)-activated potassium (BK) channels (maxi-K(+)-channels) hyperpolarize the cell membrane thus supporting Ca(2+) entry through Ca(2+)-release activated Ca(2+) channels. Janus kinase-2 (JAK2) has been identified as novel regulator of ion transport. To explore whether JAK2 participates in the regulation of BK channels, cRNA encoding Ca(...

Journal: :Journal of neurophysiology 2011
Ingrid van Welie Sascha du Lac

Large conductance K(+) (BK) channels are a key determinant of neuronal excitability. Medial vestibular nucleus (MVN) neurons regulate eye movements to ensure image stabilization during head movement, and changes in their intrinsic excitability may play a critical role in plasticity of the vestibulo-ocular reflex. Plasticity of intrinsic excitability in MVN neurons is mediated by kinases, and BK...

Journal: :American journal of physiology. Heart and circulatory physiology 2015
Xiaoxiao Tao Mike T Lin Glyne U Thorington Sean M Wilson Lawrence D Longo David A Hessinger

Acclimatization to high-altitude, long-term hypoxia (LTH) reportedly alters cerebral artery contraction-relaxation responses associated with changes in K(+) channel activity. We hypothesized that to maintain oxygenation during LTH, basilar arteries (BA) in the ovine adult and near-term fetus would show increased large-conductance Ca(2+) activated potassium (BK) channel activity. We measured BK ...

Journal: :Circulation Research 2003

Journal: :Journal of General Physiology 2004

Journal: :American journal of physiology. Cell physiology 2014
Kiril L Hristov Amy C Smith Shankar P Parajuli John Malysz Georgi V Petkov

Large-conductance voltage- and Ca(2+)-activated K(+) (BK) channels are critical regulators of detrusor smooth muscle (DSM) excitability and contractility. PKC modulates the contraction of DSM and BK channel activity in non-DSM cells; however, the cellular mechanism regulating the PKC-BK channel interaction in DSM remains unknown. We provide a novel mechanistic insight into BK channel regulation...

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