INTRODUCTION Circulatory failure during brain death organ donor resuscitation is a problem that compromises recovery of organs. Combined administration of steroid, thyroxine and vasopressin has been proposed to optimize the management of brain deceased donors before recovery of organs. However the single administration of hydrocortisone has not been rigorously evaluated in any trial. METHODS ...

BACKGROUND The aim of life-support measures in brain-dead donors is to preserve the functional value of their organs. In renal transplantation, serum creatinine level is one of the criteria for graft harvest. The aim of this study was to assess the impact of intensive care on donor renal function through two criteria: preharvesting serum creatinine level above 120 micromol/L and the elevation o...

background and aims: there are different causes for brain death including head trauma, cerebrovascular accidents and intracranial space-occupying lesions. the present study was aimed to determine the causes of brain death in chahar mahal and bakhtiari province due to high turnover of trauma in this area during 2003 to 2013. methods: this study was based on routine data and was conducted on all ...

BACKGROUND Heart donation after circulatory determination of death (DCDD) has provoked ethical debate focused primarily on whether heart DCDD donors are dead when death is declared and when organs are procured. OBJECTIVE AND DESIGN We rigorously analyse whether four heart DCDD programmes (Cape Town, Denver, Australia, Cambridge) respect the dead donor rule (DDR), according to six criteria of ...

Rationale: Donor brain death (BD) is an unavoidable occurrence in heart transplantation and results in profound physiological derangements that render the heart more susceptible to ischemia/reperfusion injury in the recipient and likely has negative long-term consequences to allograft survival. Objective: We developed a novel mouse model of BD and investigated the role of complement in BD-induc...

RATIONALE Donor brain death (BD) is an unavoidable occurrence in heart transplantation and results in profound physiological derangements that render the heart more susceptible to ischemia/reperfusion injury in the recipient and likely has negative long-term consequences to allograft survival. OBJECTIVE We developed a novel mouse model of BD and investigated the role of complement in BD-induc...

BACKGROUND Although it has been shown that a vagus nerve stimulation of brain dead (BD) donors leads to an improvement of renal function in recipients in an acute allograft rejection model, its influence on chronic allograft nephropathy is still unknown. In the present study, we assessed the influence of donor vagus nerve stimulation on survival, renal function and histology in a chronic allogr...

Between October 1998 and May 2010, 158 lung transplants were performed in seven centers in Japan. Living-donor lobar lung transplantation (LDLLT) has been performed more than cadaveric lung transplantation (CLT) because of the difficulty in obtaining brain dead donors (n = 93 versus n = 65). The indications were quite unique in Japan where idiopathic pulmonary arterial hypertension was the most...

Organ transplantation is the only curative option available for many diseases resulting in irreversible organ-failure. Advanced surgical-techniques, perioperative care and immunosuppressive therapy have tremendously improved survival rates in patients undergoing transplantation. However, the primary impediment in the progress of transplantation in our country is the lack of donor organs. Ever s...