Bleomycin (BLM), discovered by Umezawa et al. (1966a, b) is a kind of cytostatic antibiotic complex produced by a strain of Streptomyces verticillus, and was found by Ichikawa et al. (1967, 1968) to be highly effective against human squamous cell carcinoma. These authors observed relatively high concentration of BLM in the skin after subcutaneous injection in mice, and suggested that the therap...

The depolarization-dependent uptake of calcium was studied in synaptosomes isolated from whole mouse brain and regions of rat brain. In vitro addition of A’-tetrahydrocannabinol (THC) inhibited calcium uptake. The brainstem was most sensitive to this effect-a lo-@ M THC concentration was sufficient to inhibit uptake by synaptosomes from this region. Cannabidiol produced effects similar to those...

Abstract Forty years of studies on bioelectromagnetics, in our laboratory, are presented to view new horizons electromagnetics medicine and biology. The several topics reviewed discussed. review includes transcranial magnetic stimulation (TMS) the human brain, imaging electrical information brain based resonance (MRI) such as impedance MRI current MRI, cancer therapy using magnetizable beads pu...

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder in which the aggregation and deposition of amyloid-β (Aβ) peptides in the brain are central to its pathogenesis. In healthy brains, Aβ is effectively metabolized with little accumulation. Cellular uptake and subsequent degradation of Aβ is one of the major pathways for its clearance in the brain. Increasing ev...

Thirty six patients in the chronic stage after severe closed head injury were examined with tests of executive function, memory, intelligence, and functional capacities in daily living. Correlations were sought between test results and Tc-99m-HMPAO uptake of frontal, temporal, and thalamic regions assessed by SPECT. Neither the number of significant correlation coefficients between memory tests...

An acute increase in plasma tonicity results in an adaptive increase in brain organic osmolyte content, but this process requires several days to occur. Slow reaccumulation of brain organic osmolytes may contribute to osmotic demyelination. It was investigated whether administration of intravenous myoinositol in rats could speed entry of the osmolyte into the brain. Two groups of animals were s...

Nicotine, the major component of tobacco smoke (TS) and electronic cigarette (e-cig) vape, has been reported in some cases to be prodromal cerebrovascular toxicity as well a promoting factor for onset various neurological diseases. In conditions, pre-exposure nicotine can lead state compromised blood-brain barrier (BBB) integrity, including altered BBB-related protein expression, BBB leakage, d...

Autoradiographic patterns of [14C]2-deoxyglucose uptake are described throughout the brains of hibernating and euthermic ground squirrels. Autoradiographs of the brains of hibernating animals are generally homogeneous in comparison to euthermic animals; hence, the relative 2-deoxyglucose uptake (RBDGU) of gray to white matter for the majority of the 85 neural structures examined decreases durin...

A technique has been developed for injecting metallic mercury intravenously in aqueous solution. Thirty seconds after intravenous injection of rats with oi ,ug. metallic mercury labelled with 203Hg nearly 20% of the dose had been exhaled and the concentration in the brain was nearly as high as in the blood. After injection of mercuric ion little of the dose was exhaled, and brain uptake was muc...

UNLABELLED This study was performed to investigate lesions with ring-like thallium-201 (201Tl) uptake and to determine whether SPECT provides any information in differential diagnosis. METHODS A total of 244 201Tl SPECT images were reviewed. In each study, early (15 min postinjection) and late (3 hr) brain SPECT images were obtained with 111 MBq of 201Tl. The early uptake ratio (ER; lesion to...