We tested the hypothesis that thermal tail-flick latency, a common measure of pain sensitivity in rodents, would be altered in lines of mice that had been selectively bred for high voluntary wheel-running behavior. Specifically, we predicted that the selected (High-Runner) lines would show decreased pain sensitivity relative to their control (C; randombred) lines, and would respond differently ...

Two mouse lines transgenic with the human poliovirus receptor gene (PVR), TGM-PRG-1 and TGM-PRG-3, were characterized to determine whether transgene copy number and PVR expression levels influence susceptibility to poliovirus. The mouse lines have been bred for more than 10 generations and the transgene was stably transmitted to progeny as determined by Southern blot hybridization and restricti...

Relative weights of heart, spleen, pancreas, and liver and the relative lengths of the small intestine and the cecum were taken from 40 farm-bred and 43 wild juvenile red-legged partridges (Alectoris rufa Linnaeus) in central Spain. Expressed as a ratio to head and body length, farm-bred partridges had lighter hearts (17% lighter), spleens (78%), and livers (29%) and shorter small intestines (1...

Exercise is known to be rewarding and have positive effects on mental and physical health. Excessive exercise, however, can be the result of an underlying behavioral/physiological addiction. Both humans who exercise regularly and rodent models of exercise addiction sometimes display behavioral withdrawal symptoms, including depression and anxiety, when exercise is denied. However, few studies h...

The purpose of the present study was to partially phenotype male and female rats from generations 8-10 (G8-G10) that had been selectively bred to possess low (LVR) vs. high voluntary running (HVR) behavior. Over the first 6 days with wheels, 34-day-old G8 male and female LVRs ran shorter distances (P < 0.001), spent less time running (P < 0.001), and ran slower (P < 0.001) than their G8 male an...

background: balantidium coli infects humans, primates and pigs, causing serious diarrhea and dysentery. little information on the prevalence of b. coli in primates is available in china. this investigation was conducted to determine the prevalence of b. coli infection in bred rhesus monkeys in guangxi zhuang nationality autono-mous region (gznar), southern china. methods: a total of 120 fecal s...

The endocannabinoid system serves many physiological roles, including in the regulation of energy balance, food reward, and voluntary locomotion. Signaling at the cannabinoid type 1 receptor has been specifically implicated in motivation for rodent voluntary exercise on wheels. We studied four replicate lines of high runner (HR) mice that have been selectively bred for 81 generations based on a...

As reported previously, artificial selection of house mice caused a 2.7-fold increase in voluntary wheel running of four replicate selected lines compared with four random-bred control lines. Two of the selected lines developed a high incidence of a small-muscle phenotype ("mini muscles") in the plantar flexor group of the hindlimb, which apparently results from a simple Mendelian recessive all...

The opioid system is well-known for its role in modulating nociception and addiction development. However, there are premises that the endogenous may also affect blood pressure. main goal of present study was to determine impact different activity pharmacological blockade on Moreover, we examined vascular function hyper- hypoactive states modification. In our study, used two mouse lines which d...

Exercise is a naturally rewarding behaviour in human beings and can be associated with feelings of euphoria and analgesia. The endocannabinoid system may play a role in the perception of neurobiological rewards during and after prolonged exercise. Mice from lines that have been selectively bred for high voluntary wheel running (high runner or HR lines) may have evolved neurobiological mechanism...