Francisella tularensis, a Gram-negative facultative intracellular pathogen infecting principally macrophages and monocytes, is the etiological agent of tularemia. Macrophage responses to F. tularensis infection include the production of pro-inflammatory cytokines such as interleukin (IL)-12, which is critical for immunity against infection. Molecular mechanisms regulating production of these in...

Src-homology-2-containing inositol-5´-phosphatase, SHIP (also known as SHIP1), is a tumor suppressor that negatively regulates the phosphatidylinositol 3-kinase (PI3K) pathway by hydrolyzing the PI3K-generated second messenger phosphatidylinositol-3,4,5-triphosphate (PIP 3) to PI-3,4-P 2. SHIP expression is restricted primarily to hematopoietic cells, but has also been reported in mesenchymal s...

After it had been shown that the phenyl ether of ethylene glycol possessed antibacterial properties against Pseudomonas aerunosa (Berry, 1944) the antimicrobial and pharmacological activities of a number of related compounds were evaluated. Two of the compounds investigated in this connection have found clinical usefulness. These are mephenesin,3-o-toloxy-1, 2propanediol, widely used as a muscl...

Permanent growth of the container shipbuilding has led to the need of research – developing activities with references to design and ship building process. The requirements for the container vessels have been modified and changed compared with the ships built in the eighties of the past century. The ships capacity have been increased up to and even above 10 000 twenty feet containers (TEU) with...

the protection of creditors and making suitable security for their rights will result in their trust for the investment and will lead to the briskness of the trade and economic growth. one of the most important problems is the protection of creditors against contracts that debtors conclude them with the intention of escape from the payment of their debts. in this study the validity of these con...

Background: The development of resistance to antimicrobial agents is a major problem in chemotherapy. Finding agents which potentiate antimicrobial activity could be favorable. There are some reports that methylxanthines changed the inhibitory effect of antibacterial agents. Thus, possible synergistic effect of methylxanthines, aminophylline and caffeine on some antibiotics, carbenicillin, ceft...

Original scientific paper Since an evident tendency of the shipbuilding is that the sizes of ships are larger and larger, the dynamic interactions between the propulsion system and ship hull in large scale ships are much severer than those of the small sized ships. Ship hull deformations caused by the action of heavy excited wave forces could affect the vibration characteristics of the propulsi...