There is compelling evidence that interstitial inflammation plays a central role in the loss of renal function in chronic renal disease. The combined effects of interstitial inflammation, oxidative stress and local angiotensin II activity result in the disruption of glomerulus-tubule continuity, the development of pathogenic hypoxia, the generation of myofibroblasts and fibrosis, and the impair...

There is compelling evidence that interstitial inflammation plays a central role in the loss of renal function in chronic renal disease. The combined effects of interstitial inflammation, oxidative stress and local angiotensin II activity result in the disruption of glomerulus-tubule continuity, the development of pathogenic hypoxia, the generation of myofibroblasts and fibrosis, and the impair...

We have determined the amino acid sequence of the variable (V) region of the 8 heavy (H) chain of human IgD isolated from the plasma ofmyeloma patient WAH. This V region is unusual in its amino end group (arginine) and in its length (129 residues). The length is due to 10 insertions in the third complementarity-determining region (CDR3). A computer search showed that no reported CDR3-joining re...

SINCE ITS DISCOVERY over a decade ago, the NLRP3 inflammasome has been the focus of intense investigation. Although much has been learned about the molecular regulation of this potent inflammatory complex, there are several unanswered questions about what drives its assembly. At its simplest, the inflammasome is a cytosolic complex of proteins that functions to cleave and release the cytokines ...

In the July 1997 issue of the Survey of Current Business the Bureau of Economic Analysis presented new methods for the measurement of capital in the U.S. National Income and Product Accounts. This is one of the most important advances in national accounting since the creation of the United Nations (1968) System of National Accounts and presents the critical challenge to members of the Canberra ...