The effect of physiological concentrations of caffeine (purified from Persian tea) on adenosine deaminase (ADA) activity at physiological and pathological concentrations of adenosine (as substrate) in 50 mM Tris-HCl buffer (pH 7.3) at 37°C was investigated, using UV-VIS spectroscopy. ADA exhibited a bi-phasic activity behavior and both phases showed positive cooperativities indicating adenosine...

Background: The development of resistance to antimicrobial agents is a major problem in chemotherapy. Finding agents which potentiate antimicrobial activity could be favorable. There are some reports that methylxanthines changed the inhibitory effect of antibacterial agents. Thus, possible synergistic effect of methylxanthines, aminophylline and caffeine on some antibiotics, carbenicillin, ceft...

AIM To assess caffeine intake habits of Osijek high school students and identify the most important sources of caffeine intake. METHODS Adjusted Wisconsin University Caffeine Consumption Questionnaire was administered to 571 high school students (371 boys and 200 girls in the ninth grade) from Osijek, the largest town in eastern Croatia. The level of caffeine in soft drinks was determined by ...

Because caffeine may induce cyst and kidney enlargement in autosomal dominant polycystic kidney disease (ADPKD), we evaluated caffeine intake and renal volume using renal ultrasound in ADPKD patients. Caffeine intake was estimated by the average of 24-h dietary recalls obtained on 3 nonconsecutive days in 102 ADPKD patients (68 females, 34 males; 39 ± 12 years) and compared to that of 102 healt...

background: molecular targeted therapy by different cell death inducers are recently considered in cancer therapy. the aim of this study was to compare the effect of cisplatin and inositol trisphosphate kinase inhibitor (caffeine) on human breast cancer cell line (mcf-7). the pattern of cell death in mcf-7 cells following the exposure to cisplatin and caffeine in individual and combination form...

OBJECTIVE To determine whether caffeine consumption affects bronchoprovocation challenge (BPC). DESIGN A prospective, double-blind, placebo-controlled, randomized, crossover trial. PATIENTS Eleven nonsmoking men, aged 18 to 42 years, with normal baseline spirometry and evidence of exercise-induced bronchospasm. INTERVENTION On three separate test days, each individual received, in random ...

Caffeine (1,3,7-trimethylxanthine) is a popular mild central nervous system stimulant found in the leaves, seeds and fruits of various plants and in foodstuffs such as coffee, tea, and chocolate, among others. Caffeine is widely used and is not associated with severe side effects when consumed at relatively low doses. Although rarely observed, overdoses can occur. However, only a few fatal caff...

Caffeine is commonly prescribed in the NICU to treat apnea of prematurity. This review is an update based on current knowledge of the mechanisms of action, pharmacologic properties, clinical effects, and safety of caffeine in the neonatal population. Recent studies of caffeine in the neonatal population confirm its efficacy in treating apnea-related symptoms and reveal additional significant be...