results the chemical analysis of s. khuzestanica essential oil revealed the presence of carvacrol (94.1%) as its main component. the inhibition zone diameters of s. khuzestanica essential oil and carvacrol dose-dependently increased. the minimum inhibitory concentration (mic) values of s. khuzestanica essential oil and carvacrol were 0.14 ± 0.08 µl/ml and 0.09 ± 0.04 µl/ml, respectively. s. khu...

Thymus species essential oils are widely used in aromatherapy to treat several ailments. However, there is no report on their safety. In this study, we propose to investigate the acute toxicity of T. leptobotrys and T. broussonetii essential oils. These two species were selected on the basis of their frequency of medicinal use and commercial importance. Chemical analysis of these two species es...

There is an increasing need for natural compounds pest control and food preservation in agriculture, dairy industries. To satisfy this need, essential oils (EOs) from aromatic plants can serve as flavors, preservatives ecofriendly pesticides. This study investigated the potential of different EOs field-collected leaves fourteen Zataria multiflora Boiss. populations representing three chemotypes...

Background and Objective: A huge amount of investigational evidence support a role for oxidative stress as an intermediary of nerve cell dysfunction in Parkinson’s disease (PD). Polyphenols such as carvacrol have been indicated to prevent neuronal deterioration caused by increased oxidative load, thus, this study evaluated whether carvacrol administration would attenuate behavioral abnormalitie...

In the present research the antimicrobial activity of two active packaging materials on the spoilage microbiota of fresh salmon fillets was tested. A PET-coated film (PET: Polyethylene Terephthalate) containing lysozyme and lactoferrin was tested in parallel with a carvacrol-coextruded multilayer film. Salmon fillet samples were stored up to four days at 0 and 5 ̋C, comparatively. The carvacrol...

BACKGROUND A comparative analysis by using static headspace (HS) and steam distillation (SD) GC-MS of the volatile and the semi-volatile secondary metabolites from leaves of cultivated Majorana syriaca. METHODS The essential oils endogenous to cultivated thyme were isolated and identified by HS-GC-MS technology and compared to those from SD-GC-MS. RESULTS The HS-GC-MS results showed that th...

Therapeutic hypothermia is a promising new strategy for neuroprotection. However, the methods for safe and effective hypothermia induction in conscious patients are lacking. The current study explored the Transient Receptor Potential Vanilloid 3 (TRPV3) channel activation by the agonist carvacrol as a potential hypothermic strategy. It was found that carvacrol lowers core temperature after intr...

Essential oils from oregano (Origanum vulgare L.), mint (Mentha piperita L.), fennel (Foeniculum vulgare Mill.), and pine (Abies alba Mill.) needles and cones, and their active substances thymol, carvacrol, menthol, and anisaldehyde were tested for antifungal activity against Penicillium verrucosum. The lowest minimal inhibitory concentrations (MICs) were achieved for essential oil of oregano, ...

Listeria monocytogenes is a Gram-positive microorganism responsible for one of the most serious food-borne diseases in the world, listeriosis. The aim of this study is to evaluate the combined effect of a heat pretreatment with the use of antimicrobials, nisin and carvacrol, on the growth of L. monocytogenes, and their potential uses as food preservatives. Carvacrol showed a dose-dependent inhi...

PURPOSE The aim of this study was to evaluate the effects of pomegranate (PMG) extract and carvacrol (CARV) on methotrexate (MTX)-induced oxidative stress and bone marrow toxicity. METHODS Wistar albino rats (32 rats) were divided into four groups (n=8): Group 1 was control; Group 2 was given a single intraperitoneal injection of methotrexate (20 mg/kg); Group 3 was treated with carvacrol (73...