Cellulose is the most abundant biopolymer in the world, the main load-bearing element in plant cell walls, and represents a major sink for carbon fixed during photosynthesis. Previous work has shown that photosynthetic activity is partially regulated by carbohydrate sinks. However, the coordination of cellulose biosynthesis with carbohydrate metabolism and photosynthesis is not well understood....

In plants, cellulose biosynthesis is an essential process for anisotropic growth and therefore is an ideal target for inhibition. Based on the documented utility of small-molecule inhibitors to dissect complex cellular processes we identified a cellulose biosynthesis inhibitor (CBI), named acetobixan, by bio-prospecting among compounds secreted by endophytic microorganisms. Acetobixan was ident...

INTRODUCTION Pneumothorax is either primary or secondary. Secondary pneumothorax is usually due to trauma, including various non-pharmacologic iatrogenic triggers. Although not normally thought of as an adverse drug event (ADE) secondary pneumothorax is associated with numerous drugs, though it is often difficult to determine whether this association is causal in nature, or reflects an epipheno...

BACKGROUND Group cognitive behavioural intervention (CBI) is effective in reducing low-back pain and disability in comparison to advice in primary care. The aim of this analysis was to investigate the impact of compliance on estimates of treatment effect and to identify factors associated with compliance. METHODS In this multicentre trial, 701 adults with troublesome sub-acute or chronic low-...

BACKGROUND Effective, evidence-based interventions to prevent childhood tuberculosis (TB) in high TB/HIV-burden, resource-limited settings are urgently needed. There is limited implementation of evidence-based contact management strategies, including isoniazid preventive therapy (IPT), for child contacts of TB cases in Lesotho. METHODS/DESIGN This mixed-methods implementation science study ut...

Purpose: To determine psychometric properties of the Caring Behaviors Inventory-24 (CBI-24) among Korean clinical nurses.Methods: A methodological design was used. Data were collected from 408 nurses. Construct validity analysis performed, including factorial, convergent, and discriminant validity. Internal consistency tested by Cronbach’s ⍺ coefficients, inter-item correlation, corrected item-...

Keratoconus (KC) is a progressive non-inflammatory ectatic corneal disease typified by thinning and conical protrusion, as well irregular astigmatism with varying-degree visual impairment. A literature review on the epidemiology, classification diagnosis presented. Current clinical practice most commonly relies Krumeich’s adaptation of ABCD grading system M. Belin Amsler. The KC requires compre...