Chronic human exposure to Cd results in kidney injury. It has been proposed that nephrotoxicity produced by chronic Cd exposure is via the Cd-metallothionein complex (CdMT) and not by inorganic forms of Cd. If this hypothesis is correct, then MT-null mice, which cannot form CdMT, should not develop nephrotoxicity. Control and MT-null mice were injected s.c. with a wide range of CdCl2 doses, six...

Objectives Transabdominal ultrasonography (US) has been reported as a useful tool for evaluating Crohn's disease (CD) activity. Endoscopic findings and activity index (CDAI) are currently considered the gold standard assessing CD We assessed correlation between US double-balloon endoscopy (DBE), CDAI Methods analyzed patients with undergoing DBE within 10 days procedures. The intestine was divi...

BACKGROUND AND AIMS A general dysbiosis of the intestinal microbiota has been established in patients with Crohn's disease (CD), but a systematic characterisation of this dysbiosis is lacking. Therefore the composition of the predominant faecal microbiota of patients with CD was studied in comparison with the predominant composition in unaffected controls. Whether dysbiosis is present in relati...

Recent genome-wide association studies (GWAS) have revealed genetic risk factors in autoimmune and inflammatory disorders. Several of the associated genes and underlying pathways are shared by various autoimmune diseases. Rheumatoid arthritis (RA) and coeliac disease (CD) are two autoimmune disorders which have commonalities in their pathogenesis. We aimed to replicate known RA loci in a Dutch ...

BACKGROUND Treatment of celiac disease (CD) is based on the avoidance of gluten-containing food. However, it is not known whether trace amounts of gluten are harmful to treated patients. OBJECTIVE The objective was to establish the safety threshold of prolonged exposure to trace amounts of gluten (ie, contaminating gluten). DESIGN This was a multicenter, double-blind, placebo-controlled, ra...

Twenty six α-substituted N₄-acetamide derivatives of ciprofloxacin (CIPRO) and norfloxacin (NOR) were synthesized and assayed for antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and Bacillus subtilis. The derivatives were primarily more active against Gram-positive bacteria. The CIPRO derivatives, CD-7 (Ar = 3-chlorophenyl), CD-9 (Ar = 2-pyrimidyl)...

In the title compound, [Cd(C(9)H(10)NS(2))(2)(C(10)H(8)N(2))]·CHCl(3), the Cd(II) atom exists in an all-cis distorted octa-hedral geometry. Chelation is isobidentate for one dithio-carbamate ligand and anisobidentate for the other. The chloroform solvent mol-ecule is disordered over two positions of equal occupancy.

Charged cyclodextrin (CD) derivatives were used as chiral selectors in electrokinetic chromatography (EKC) for the chiral separation of highlyhydrophobic neutral racemates such as atropisomeric polychlorinated biphenyls (PCBs). -CD-phosphated, -CD sulfated, succinylated-CD (Succ-CD) and succinylated-CD (Succ-CD) were used as anionic CDs. As cationic CD, 6-monodeoxy-6-monoamino-CD ( -CD-NH2) was...

The coordination geometry of the Cd(II) atom in the title complex, [Cd(NCO)(2)(C(10)H(14)N(4))(2)](n) or [Cd(NCO)(2)(bimb)(2)](n), where bimb is 1,4-bis-(imidazol-1-yl)butane, is distorted octa-hedral with the Cd(II) atom located on an inversion center and connected to four N atoms from the imidazole units of four symmetry-related bimb ligands and two O atoms from two symmetry-related NCO(-) li...