Background: CD93 has originally been known as a C1q receptor, and many studies have demonstrated that CD93 is expressed on hematopoietic stem cells, B cell progenitors, myeloid and monocytic cells. Moreover, CD93 is shown to be expressed on long-lived plasma cells, and CD93 deficient-mice display an impairment in plasma cell development. Objective: To investiga...

Abstract Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Ig?), signaling component preB cell receptor (preBCR), to be associated with CNS-infiltration –relapse B-cell precursor (BCP)-ALL patients. Furthermore, show that downregulation hampers engraftment cells diffe...

Background & objective: Globally, breast cancer is the most common malignancy among females. Prohibition (PHB)-I, a homologous protein, was initially introduced as a suppressor gene for amplification process. Further, the protein has a key role in the cell cycle and is capable of inhibiting DNA transcription in many cell types. Therefore, its possible role in different...

Background: The purpose of this study was to examine the impact of Insulin (INS) on human sperm function, in light of a recent proteomic analysis indicating that these cells express the INS receptor (INSR). Materials and Methods: We used Western blot and Immunocytochemical analyses. Results: Immunocytochemical analyses confirmed the presence of INSR in human spermatozoa and localized this recep...

ObjectiveTo summarize recent therapeutic developments for chronic pruritus with a focus on allergic and type 2 inflammatory pathways.Data SourcesLiterature search of PubMed, industry websites, review the ClinicalTrials.gov database.Study SelectionsPeer-reviewed publications public disclosures by relating to pathophysiology therapeutics.ResultsHistamine immunoglobulin E remain primary targets tr...

Abstract Background Abscission is an active, organized, and highly coordinated cell separation process enabling the detachment of aerial organs through modification cell-to-cell adhesion breakdown walls at specific sites on plant body known as abscission zones. In Arabidopsis thaliana , floral cauline leaves regulated by interaction hormonal peptide INFLORESCENCE DEFICIENT IN ABSCISSION (IDA), ...

From their first contact with continuously cultured ZF4 cells, 10, 30 and 100 nm PVP-capped AgNPs induce receptor mediated endocytotic processes, cellular repair mechanisms, at higher doses, cell death via autophagy, apoptosis or necrosis.

Objective(s): Cells perform their functional activities by communicating with each other through endogenous substances and receptors. Post-translation, stem cells function properly in new host tissue by carrying specific cell surface receptors. We aimed to characterize muscarinic receptor subtypes in mesenchymal stem cells (MSCs) together with osteogenic and adipogenic...

Skin aging, represented by wrinkles, is caused a decrease in the dermal components such as collagen, elastin, and fibroblast. Extracellular vesicles (EVs) mediate cell-to-cell communication via cargo biomolecules cell-free manner. In previous studies, we produced mesenchymal stem cell (MSC)-derived cargo-regulated EVs through various priming methods reported that these affect progression of dis...