introduction: it has been demonstrated that the adrenal medullary transplants into the spinal subarachnoid space can alleviate neuropathic pain behaviors. the aim of the present study was to test the possibility that histological changes of the sciatic nerve in a neuropathic model as well as sensory dysfunction are repaired by adrenal medullary transplantation. material and methods: left sciati...

Chronic obstructive pulmonary disease (COPD) is characterized by tissue loss and a growing restriction of airflow. Due to chronic inflammation brought on extended exposure noxious particles or gases, most often cigarette smoke, it linked structural abnormalities in the lungs. Airway constriction reduction lung recoil are results inflammation. In affluent countries, majority COPD cases caused to...

BACKGROUND Evidence has been generated that various anticonvulsant agents provide relief of several chronic pain syndromes and therefore as an alternative to opioids, nonsteroidal anti-inflammatory, and tricyclic antidepressant drugs in the treatment of neuropathic pain. The results of these studies thus raise the question of whether all anticonvulsant drugs or particular mechanistic classes ma...

Neuropathic pain is a chronic condition that significantly reduces the quality of life many patients as result ineffective relief therapy. For reason, looking for new analgesics remains an important issue. Mirogabalin gabapentinoid specific ligand α2σ-1 and α2σ-2 subunits voltage-gated calcium channels. In present study, we compared analgesic effect pregabalin mirogabalin in neuropathic constri...

Pulpal and periradicular pathology is the common sequel following trauma to teeth severe enough cause displacement of tooth resulting in necrosis pulp as a result severing neurovascular supply near apical constriction. This case report evidenced conservative non-surgical endodontic management large periapical lesion 19-year-old young male induced due traumatic injury face.

Ventilator-induced lung injury has been proposed as being caused by overdistention and closure and reopening of small airways and alveoli. Here we investigate the possibility that heterogeneous constriction increases airflow-related shear stress to a dangerously high level that may be sufficient to cause injury to the epithelial cells during mechanical ventilation. We employed an anatomically c...

please cite this article as : moini zanjani t, saghaei e, ameli h, sabetkasaei m. anti-allodynic effect of nefopam and morphine in a rat model of neuropathic pain. novel biomed 2013;1:16-22. background: neuropathic pain is a chronic pain due to a disorder in the peripheral or central nervous system with different pathophysiological mechanisms. current treatments are not effective. here we compa...

Ozone is widely used to relieve chronic pain clinically, but the precise mechanisms governing its action have yet be elucidated. The present study aimed investigate underlying pain‑alleviating effect of ozone in constriction injury (CCI) model sciatic nerve rats. Pain behaviours rats were assessed by mechanical allodynia and thermal hyperalgesia. expression spinal glutamate receptor 6 (GluR6) N...