In this study, we showed that the dual addition of glucosyl ceramide synthase and ceramidase inhibitors to A549 cell culture led to the possibility of ceramide channel formation via endogenous palmitoyl-ceramide accumulation with an increase in cholesterol contents in the lysosome membrane as an initial step prior to initiation of necrotic cell death. In addition, the dual addition led to black...

Leukocyte segmentation is one of the essential steps in an automatic leukocyte recognition system. Due to the complexity of the overlapping cell images, methods for leukocyte segmentation are still needed. In this paper, we first construct a combined image by saturation and green channels to extract the nucleus and in turn locate a cursory circular region of the leukocyte. Then the boundary of ...

Throughput and energy efficiency in 3-way relay channels are studied in this paper. Unlike previous contributions, we consider a circular message exchange. First, an outer bound and achievable sum rate expressions for different relaying protocols are derived for 3-way relay channels. The sum capacity is characterized for certain SNR regimes. Next, leveraging the derived achievable sum rate expr...

Permineralized wood from the middle of the Upper Triassic Petrified Forest Formation in Arizona, in strata correlative with the Sonsela Member, displays various forms of heartwood degradation. Pitting of the wood exhibits two primary morphologies. Elongated cavities are up to several mm long, parallel to the wood grain and may merge to form channels that extend longitudinally through the wood f...

Heat transfer to a fluid passing through a channel filled with porous materials is the subject of this investigation. It includes the derivation of the temperature solutions in channels having different cross sectional geometries. Primarily, consideration is given to a modified Graetz problem in parallel plate channels and circular tubes. This presentation includes numerical features of the exa...

in this study, the vibration behavior of functional graded (fg) circular and annular nanoplate embedded in a visco-pasternak foundation and coupled with temperature change is studied. the effect of in-plane pre-load and temperature change are investigated on the vibration frequencies of fg circular and annular nanoplate. to obtain the vibration frequencies of the fg circular and annular nanopla...

today, many companies have multiple channels, such as sales force, direct mail / catalog, internet and broadcast channels, telephone, etc. for providing goods and services to its customers. multiple distribution channels, despite having benefits, several challenges such as the incidence of conflict, allocation of product, free ride some members have being emerged. the aim of this study was to i...

purpose: the aim and objective of this report is to identify the benefits of interactive communication channels and to advice the fmcg business on how these new methods are better than the conventional methods. design/ methodology/approach:  in this research article facts about advertisement and its effectiveness were collected from different surveys conducted by various agencies. mainly second...

Microchannels typically have rectangular cross-sections, whereas biological channels, such as blood vessels and airways, circular cross-sections. The difference in cross-sections causes different fluidic behaviors, resulting differences between behavior microchannels channels. To simulate vitro, cross-sectional are required. We developed a microchannel with smooth channel wall, free from cracks...