Idiosyncratic drug-induced liver injury (DILI) is an underreported and underestimated adverse drug reaction. Information on the documented hepatotoxicity of drugs has recently been made available by a website that can be accessed in the public domain: LiverTox (http://livertox.nlm.nih.gov). According to critical analysis of the hepatotoxicity of drugs in LiverTox, 53% of drugs had at least one ...

A stability-indicating LC assay method was developed and validated for a simultaneous determination of meropenem and potassium clavulanate in the presence of degradation products formed during acid-base hydrolysis, oxidation and thermolysis. The isocratic RP-HPLC method was developed with a LiChrospher RP-18 (250 mm x 4.6 mm, 5 microm) column and gradient elution of 12 mmol/L ammonium acetate a...

The genus Acinetobacter currently contains 34 species, the vast majority of which are not regularly implicated in causing infection. However, Carbapenems have long been thought as agents choice for serious baumannii infections. objective this study is to determine Antibiotics susceptibility profile spp Isolated from clinical specimen University Ilorin Teaching Hospital, Ilorin. descriptive cros...

Aim To investigate the efficacy and safety of home-treatment with oral piv-mecillinam or amoxicillin-clavulanate in children acute pyelonephritis. Methods Children aged over 6 months diagnosed culture confirmed pyelonephritis at Danish Paediatric Departments were home-treated (tablets) (liquid tablets). Follow-up was performed by phone (second treatment day) clinical review patients hospital (d...