BACKGROUND Recently the laparoscopic ovarian drilling (LOD) has been used as a surgical treatment for ovulation in women with polycystic ovarian syndrome (PCOS), although its mechanism and outcomes are still unclear. This study was undertaken to evaluate the in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) outcomes in clomiphene-resistant women with PCOS who were treated wit...

THE aetiology of anencephaly and/or spina bifida (neural tube defects) is still obscure. Most investigators are now agreed on a multifactorial causation with an important genetic factor and a substantial environmental component. The genetic factor is probably polygenic, but the mechanism by which it acts remains unknown. Recently, drugs that stimulate ovulation, particularly clomiphene, have be...

Investigations into the effect of clomiphene citrate stimulation on endometrial differentiation were retrospectively performed in the mid-luteal phase on 21 patients undergoing ovulation induction prior to artificial insemination. A high incidence of irregular endometrial development was seen using morphological and morphometric criteria; in addition, increasing stromal oedema after clomiphene ...

Aim: To compare the efficacy of letrozole and clomiphene citrate in women having anovulatory infertility. Study design: Randomized Controlled Trial. Place duration study: 16th October 2020 to 15th September 2021 Department Obstetrics & Gynecology, Shahida Islam Medical Complex Lodhran. Methods: In our study 112 patients between ages 18 40 years with anovulation were included. Patients H/O p...

Clomiphene citrate is a white to pale yellow, essentially odorless, crystalline powder. It is freely soluble in methanol; soluble in ethanol; slightly soluble in acetone, water, and chloroform; and insoluble in ether. CLOMID is a mixture of two geometric isomers [cis (zuclomiphene) and trans (enclomiphene)] containing between 30% and 50% of the cis-isomer. Each white scored tablet contains 50 m...

to a receptive endometrium suitable for implantation. One of the major drugs used for infertility treatment is clomiphene citrate (a non steroidal synthetic compound with both estrogenic and anti-estrogenic activity). Clomiphene citrate stimulates ovulation by competitively inhibiting the estrogen (E) binding to the hypothalamic estrogen receptors (ER), thereby releasing the hypothalamus from t...

Polycystic ovary syndrome is an endocrinological disorder where there is hyperandrogenism, ovarian dysfunction and multiple ovarian cysts. The most common presenting features are hirsutism, acne, metabolic syndrome and biochemical hyperandrogenism. Patients also have hyperlipidemia and an impaired glucose metabolism. Treatment involves oral contraceptive pills for menstrual abnormalities and hy...