An in vitro test for the development of corneal opacity in response ocular irritants was first proposed by Muir (1984). This test required the clamping of a bovine cornea between two chambers filled with physiologic saline and measuring the transmittance of white light through the cornea using the voltage output of a photocell. This was followed by exposure of the epithelial surface of the corn...

The cornea performs two major functions: to protect the inner contents of the eye and to refract light. To do so, the cornea must maintain its strength and transparency. The main structural component of the cornea is the stroma, which provides most of the cornea’s strength, and helps give the eye its shape. The refractive power of the cornea is determined by its index of refraction and by its r...

background and purpose: microsporidiosis is one of the emerging and opportunistic infections, which causing various clinical symptoms in humans. the prevalence of this infection varies, depending on the infected organ, diagnostic methods, and geographical conditions. in the present study, we aimed to investigate microsporidial keratitis in patients referring to farabi eye hospital tehran, iran ...

purpose: to compare the clinical and paraclinical outcomes following deep anterior lamellar keratoplasty (dalk) using frozen versus fresh corneas in patients with keratoconus. methods: in this prospective, comparative interventional study, 16 frozen and 19 fresh corneas were used during dalk in keratoconus patients. big bubble technique was used in all patients. the two groups were compared at ...

PURPOSE The purpose of this study was to assess the relationship between donor factors and 5-year corneal graft survival in the Cornea Donor Study. METHODS Donor corneas met criteria established by the Eye Bank Association of America, had an endothelial cell density of 2300 to 3300/mm, and were determined to be of good to excellent quality by the eye banks. Donor corneas were assigned using a...

PURPOSE To introduce an image analysis of the cornea in photorefractive keratectomy (PRK) for preoperative and early postoperative determination of changes in the condition of the cornea. METHODS Slit-lamp videography was used to evaluate the cornea. Microdensitometry of the corneal images was performed. The optic density of the anterior, middle, and posterior corneal layers was measured. Pho...

The requirement for T cell costimulation at sites of infection and inflammation is unresolved. Herpes stromal keratitis (HSK) is a CD4+ T cell-regulated inflammatory response to herpes simplex virus type 1 infection of the cornea. Our findings suggest that susceptibility to HSK is determined by the microenvironment of the infected cornea. The cornea is normally devoid of Langerhans cells (LC), ...

Increased biochemical knowledge of normal and diseased corneas is essential for the understanding of corneal homeostasis and pathophysiology. In a recent study, we characterized the proteome of the normal human cornea and identified 141 distinct proteins. This dataset represents the most comprehensive protein study of the cornea to date and provides a useful reference for further studies of nor...

1. The penetration of sodium sulphacetaamide into the ocular tissues has been studied, both in living'rabbits and in isolated ocular tissues. 2. Application of the drug with a wetting agent, Duponal ME dry, increases the penetration of sodium sulphacetamide into and through the cornea. 3., Removal of the corneal epithelium causes a great increase in the penetration of the sulphonamide into antd...