results during the 3 months study, in the placebo group, systolic bp (sbp) increased with 6.3 mmhg and diastolic bp (dbp) increased with 4.6 mmhg, changes which were significant. after the 3 months, the effect of garlic on sbp, after adjusting for baseline value, was significant, and this effect was more significant in hypertensive patients. plasma lipids and lipoproteins did not change signific...

background: c linical trials of revascularization have routinely under-enrolled elderly subjects. thus, symptom relief and improved survival might not apply to elderly patients, in whom the risk of mortality and disability from revascularization procedures seems to be high and co-morbidity is more prevalent. the present case control study was performed to draw a comparison in terms of the proce...

background abnormalities in the velocity and pattern of myocardial shortening on tissue doppler imaging (tdi) have been proposed to aid in the noninvasive diagnosis of coronary artery disease (cad). objectives we investigated the diagnostic value of post-systolic shortening (pss), a delayed ejection velocity of the myocardium after the closure of the aortic valve, on tdi in the diagnosis of cad...

Estrogen might play an important role in the pathogenesis of diabetes mellitus type 2. Estrogens inhibit diabetes via distinct mechanisms particularly by reducing both hyperglycemia and plasma insulin levels. Estrogen exerts its physiological effects mainly through estrogen receptors including α and β types. Estrogen receptors are found in many tissues that participate in the pathogenesis of ty...

conclusions our results show a significant association of nos3 and mthfr gene polymorphisms with coronary atherosclerotic lesions. therefore, these variants might influence the risk of coronary artery disease, specifically in the iranian population. results we specifically detected the nos3 tt genotype in 12 patients (11.11%) and did not find the same genotype in any of the controls. the freque...

Coronary artery disease is one of the leading causes of mortality and diabetes mellitus is one of its main risk factors due to microvascular and macrovascular complications, such as atherosclerosis. Atherosclerosis is now known to be an inflammatory process mediated by prostaglandins and several interleukins. As both are important in inflammatory processes, we examined Cox-2 (-765G > C) polymor...

References 1. Cha E, Fu Z-Y, Ma Y-T, Zhu Q, Xie X, Liu F. A novel polymorphism of the GP78 gene is associated with coronary artery disease in Han population in China. Lipids Health Dis. 2014;13:147. 2. Zhu Q, Fu Z, Ma Y, Yang H, Huang D, Xie X, et al. A novel polymorphism of the CYP2J2 gene is associated with coronary artery disease in Uygur population in China. Clin Biochem. 2013;46(12):1047–5...