Minocycline is an antibiotic of tetracycline derivatives that is commonly used in the treatment of moderate to severe acne vulgaris. It has been reported to cause rare adverse events from mild cutaneous eruption to severe forms including drug-induced lupus, serum sickness-like reaction, and hypersensitivity reactions, etc. The risks of adverse events attributed to minocycline have not been asce...

Dear Editor, Nicotinamide with tetracycline or doxycycline is used in the treatment of bullous pemphigoid. Nicotinamide is used in doses of 1500 to 2000 mg/day in divided doses in these cases. Nicotinic acid/laropiprant (Tredaptive®) is a lipid lowering agent which contains 1000 mg of nicotinic acid (niacin) and 20 mg of laropiprant which is a selective antagonist of prostaglandin D2 receptor. ...

Background: Previous studies indicated that eosinophils infi ltrate the skin during drug eruptions and that counts may become elevated in circulation. However, little is known about the role of eosinophils in the prognosis of patients with drug eruption. Objective: This study aims to investigate the correlation between circulating eosinophil counts and the prognosis of patients with drug erupti...

The recorded reports of cutaneous eruptions due to the antihistaminic drugs have been few in number (1,2,3,4, 5, 6,7), but none of these has been truly urticarial in nature. McElin and Horton (1) in 1945 reported one instance of generalized pruritus, following thirty-eight intravenous injections of Benadryl hydrochloride in twenty-six patients. Epstein (2) reported two patients with atopic ecze...

The principles behind the primary localization of lesions in fixed drug eruption are still unknown. Studies investigating the predilection areas indicated drug-related, trauma-related or inflammation-related specific site involvement in fixed drug eruption. This study presents new findings of primary site involvement on the maximal points of Head's zones. In the 3 cases reported here, fixed dru...

how to cite this article: karimzadeh p, bakrani v. antiepileptic drug-related adverse reactions and factors influencing these reactions. iran j child neurol. 2013 summer; 7(3):23-27.   objective according to the basic role of drug side effects in selection of an appropriate drug, patient compliance and the quality of life in epileptic patients, and forasmuch as new dugs with unknown side effect...

A 21-year-old young girl presents with intense abdominal pain, nausea, diarrhea in the context of a cutaneous eruption formed by erythematous and papulous elements with brown violet aspect, very pruriginous, occasioned by the preparation of some fishmeal. Similar eruption debuted from childhood from the age of 4 year became rare with age. Since 3 years, the patient presents more intense digesti...

Self-healing juvenile cutaneous mucinosis is an extremely uncommon disorder characterized by the acute eruption of multiple papules and subcutaneous nodules. In this report, we describe one of the youngest patients reported to date with self-healing juvenile cutaneous mucinosis and further define several of the histologic and clinical characteristics unique to the disorder. Awareness of this di...