OBJECTIVES To review the reported trend of leprosy in Hong Kong. DESIGN Retrospective study. SETTING Three major leprosy clinics in Hong Kong. PATIENTS Leprosy patients registered between 1970 and 2004. MAIN OUTCOME MEASURES Incidence, rate of deformities, distribution of leprosy subtypes, age distribution, and relapses after therapy. RESULTS The incidence of leprosy has decreased fro...

STUDY OF CONTROLLED RELEASE OF DAPSONE FROM MODIFIED MONTMORILLONITE AND POLYMER MATRICES

Eosinophilic lung diseases (ELD) are a variety of several clinical entities, which may result from different etiologies, including drug treatment. Dapsone, a sulfone antibiotic widely used in leprosy (among other indications), has been described as a possible cause of ELD. We report a patient with leprosy who presented with respiratory symptoms and pulmonary infiltrates and was diagnosed as suf...

We report a case of a 19-year-old girl who presented with 5-year history of swelling of upper lip and fissured tongue treated with dapsone then oral steroids without any improvement. Clinical examination found peripheral facial nerve paralysis and Labial mucosa biopsy showed non-necrotizing giganto-epithelioid granuloma. Diagnosis of Melkersson-Rosenthal syndrome was retaind because of associat...

A 73-year-old man was admitted in respiratory failure that had subacutely progressed after five weeks of dapsone treatment for a skin rash. He also presented with fever, systemic erythroderma and liver dysfunction. Chest computed tomography showed diffuse reticular shadows with ground-glass opacity and bilateral mediastinal lymphadenopathy. Lymphocytes, but not eosinophils, were increased in th...

The recommendation of the WHO Study Group to introduce MDT for the treatment of leprosy met with considerable resistance in Brazil. The National Department for Dermatological Disease (DNDS) advanced a number of arguments against the adoption of WHO MDT by Brazil (1) including: • significant risk of side-effects; • efficacy not proven; • lack of evidence to confirm: – speedier attainment of smea...