background and aims. oral pemphigus vulgaris is a chronic autoimmune mucocutaneous intraepithelial disease that primarily affects patients over the age of fifty, resulting in mucosal ulceration and is a potentially life-threatening disease. the purpose of this study was to investigate the efficacy of dapsone in combination with systemic corticosteroids to treat the oral lesions of oral pemphigu...

The widespread emergence of dapsone-resistant strains of Mycobacterium leprae in patients with lepromatous leprosy who had been treated with dapsone as monotherapy, is now fully accepted (WHO, 1 977). This growing problem of acquired (secondary) dapsone resistance among the large pool of dapsone­ treated lepromatous patients at risk, could be still more foreboding with the recent reports of new...

BACKGROUND Dapsone can rarely cause a hypersensitivity reaction called dapsone syndrome, consisting of fever, hepatitis, exfoliative dermatitis, lymphadenopathy and hemolytic anemia. Dapsone syndrome is a manifestation of the DRESS (drug rash with eosinophilia and systemic symptoms) syndrome which is a serious condition that has been reported in association with various drugs. Cholangitis in da...

Two hundred and twelve lepromatous patients, presenting with suspected dapsone-resistant leprosy in the 5-year period 1 973-77, were taken into trial treatment with dapsone. Clinically, 55% have been proven to be dapsone resistant and the remainder are continuing to respond to full dosage dapsone after 4·5 to 9 years. This clinical observation contrasts with results of the dapsone-sensitivity s...

19 19 QUESTIONS • CHALLENGES • CONTROVERSIES Dapsone, first developed in 1908, was initially intended for oral treatment of infectious diseases; however, dapsone was later shown to have potent anti-inflammatory properties. The anti-inflammatory mechanisms of dapsone appear to be separate from its antibacterial properties. Oral dapsone has been shown to be efficacious for dermatoses with neutrop...

Dapsone syndrome is a rare hypersensitivity reaction to dapsone and is characterized by high fever, papular or exfoliative dermatitis, progressing to liver toxicity and generalized lymphadenopathy, resembling a mononucleosis infection. We report a patient who developed acute renal failure, as well as other complications characteristic of dapsone syndrome, during leprosy treatment. Renal involve...

A prospective, randomized, crossover study was performed with seven healthy volunteers to address the effect of increased gastric pH on dapsone absorption. Subjects were randomized to receive a single 100-mg dose of dapsone or a single 100-mg dose of dapsone in addition to 30 ml of a high potency antacid 1 h before dapsone administration and hourly thereafter for a total of 10 doses. Dapsone co...

The efficacies of trimethoprim (TMP)-sulfamethoxazole (SMZ), TMP-dapsone, dapsone, and pentamidine were compared for the prevention of Pneumocystis carinii pneumonia in the corticosteroid-treated-rat model. While 11 (73%) of 15 untreated control animals had P. carinii pneumonia after 10 weeks of immunosuppression, none of the animals given 125 mg of dapsone per kg daily, weekly, biweekly, or mo...

BACKGROUND Pustular psoriasis is an uncommon psoriasis variant, clinically characterized as small sterile pustules on an erythematous base. Evidence for therapy is lacking, and many currently employed systemic therapeutics carry risks of significant side effects, without specifically targeting disease etiology which includes the aggregation of neutrophils. OBSERVATIONS We report therapy with ...

UNLABELLED Polymer-drug conjugates have significantly influenced polymer therapeutics over the last decade via controlled pharmacokinetics. Dapsone (4,4'-diamino diphenylsulphone) is not only widely used in the treatment of leprosy but forms an essential component in the treatment of autoimmune inflammatory diseases and malaria. However, its low bioavailability and non-specific distribution in ...