Dermal collagen displays a random-like structure that has a major role in strength and function of the human integument. It is hypothesised that collagen bundles align in a parallel fashion in the direction of mechanical tension during scarring, which may explain the problematic scar formation that occurs specifically at joints. Scar tissue and normal skin were biopsied from joints and control ...

Methods: Penetration studies according to OECD guidelines [1] were performed using skin samples taken from porcine ear. For enhancing the transport of the contrast agent into the skin a submicron emulsion containing 1mmol/ml Gadolinium (Gadobutrol, Gadovist, Schering, Germany) was used. The experiments were performed using the Franz-Diffusion-Cell setup, a standard device for in vitro penetrati...

Aim: Skin firmness is one of the key parameters to define skin quality and facial aging. Among minimally invasive anti-aging strategies, hyaluronic acid (HA) injection widely accepted improve quality. While most available HA injectables are designed intended for intradermal injection, a novel HA/sorbitol composition containing 2.6% high molecular weight stabilized by sorbitol was recently devel...

The efficacy of one-stage artificial dermis and skin grafting was tested in a nude rat model. Reconstruction with artificial dermis is usually a two-stage procedure with 2- to 3-week intermission. If one-stage use of artificial dermis and split-thickness skin grafting are effective, the overall burden on patients and the medical cost will markedly decrease. The graft take rate, contraction rate...

ABSTRACT Resistance of mature berries of grapevine cultivars and selections to postharvest infection by Botrytis cinerea was assessed. Little or no resistance existed in most popular table grape Vitis vinifera cultivars, except in moderately resistant 'Emperor' and 'Autumn Black'. Highly resistant grapes were V. rotundifolia, V. labrusca, or other complex hybrids. Morphological, anatomical, and...

CONTEXT AND OBJECTIVE The technique of obtaining human skin with dermis and epidermis reconstructed from cells isolated from patients can enable autologous skin grafting on patients with few donor sites. It also enables in vitro trials on chemicals and drugs. The objective of this work was to demonstrate a method for obtaining human skin composed of associated dermis and epidermis, reconstructe...

Background: Ulcers are discontinuity of skin/mucous membrane. Chronic ulcers caused by skin loss that takes long to heal. Skin grafting helps tissue regeneration, hastens healing process. grafts classified as Split-thickness and full-thickness grafts. STSG consist epidermis some layers dermis. FTSG consists epidermis, dermis, subcutaneous tissue.Methods: This retrospective prospective study was...