background: national institute of environmental health sciences (niehs) scientists shows that long-term exposure to air pollutants increases the risk of respiratory diseases such as allergies, asthma, chronic obstructive pulmonary disease, and lung cancer. children and the elderly are particularly vulnerable to the health effects of ozone, fine particles, and other airborne toxicants. air pollu...

background: hypertension is a significant public health concern of world‑wide distribution and is also the most common cardiovascular disease risk factor. adequate control of blood pressure is a critical element in the prevention of hypertension induced‑organ damage and life‑threatening complications. prevention of hypertension is possible and early detection and effective treatment can signifi...

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by a significant phenotypic variability in progression of the disease. Vascular endothelial growth factor (VEGF) has been reported to play a major role in renal pathophysiology. The aim of the present case-control study was to evaluate the association of two promoter polymorphisms (-2578C>A and -1154G>A) of VEGF gene and ADPK...

ulcerative colitis is an acute or chronic inflammatory bowel disease that diffusely involves the colonic mucosa. the etiology of ulcerative colitis is unknown. the involvement of genetic factors in ulcerative colitis is suggested by some reports of familial occurence anil the immune abnormalities found in patients and their unaffected female relatives. a number of disease with unknown etiology,...

background: paraoxonase-1(pon1), a high-density lipoprotein (hdl) associated enzyme, is believed to contribute in the patho­genesis of coronary artery disease (cad). the aim of this study was to evaluate the association of pon1 promoter c (-107)t polymorphism with the extent of coronary artery stenosis in iranian patients. methods : the rflp analysis for determination of the c(-107)t genotype d...

Fold designability has been estimated by the number of families contained in that fold. Here, we show that among orthologous proteins, sequence divergence is higher for folds with greater numbers of families. Folds with greater numbers of families also tend to have families that appear more often in the proteome and greater promiscuity (the number of unique "partner" folds that the fold is foun...

Coronavirus disease 2019 (COVID-19) was first emerged in Wuhan, China in December 2019, and on March 11, 2020, WHO announced COVID-19 outbreak as a pandemic. Because chloroquine is now one of the mainstay therapies of COVID-19 all over the world, we assumed that it may play a role in preventing COVID-19 in malaria-endemic countries. So, we decided to compare the distribution map of COVID-19 wit...

BACKGROUND & OBJECTIVES Data on infectious diseases like tuberculosis (TB) have been analyzed in the past without giving adequate attention to spatial variations. Earlier studies also attempted to display disease status of sub regions, usually census tracts, by categorizing them into quartiles, that helps the authorities to identify high- or low-risk areas. This approach is based mainly on bino...