UNLABELLED The intracellular distribution of Auger electron-emitting radiopharmaceuticals is a determinant of cytotoxicity. However, the mechanisms by which these agents are routed through the cell are ill understood. The aim of this study was to investigate how trafficking of (111)In-labeled human epidermal growth factor ((111)In-DTPA-hEGF) relates to that of the EGF receptor (EGFR) and whethe...

Absract ✓ Objective : To develop a Convolution Neural Network (CNN) and discuss its performance in the estimation of Glomerular Fifiltration Rate (GFR) for patients with chronic kidney disease (CKD). Methods A total 112 were enrolled this study. The GFR is measured by 99mTc-DTPA renal dynamic used as standard after normalization body surface area imaging. We established CNN model verified compa...

A new MRI-contrast agent, EB-DTPA-Gd, that has an Evans Blue analogue as a sensing unit for endothelium lesions, was designed and synthesized. The agent also has diethylenetriamine-N,N,N',N",N"-pentaacetic acid-Gd complex (Gadolinium-DTPA) units, which have been used as detection units for T1-weighted MRI. The EB-DTPA-Gd was able to recognize and adsorb to the vascular endothelium-denuded regio...

INTRODUCTION Delayed gadolinium enhanced MRI of cartilage (dGEMRIC) is a quantitative MRI method utilizing anionic contrast agent Gd-DTPA. The suggested mechanism is that the fixed charge density (FCD) of cartilage, induced by glycosaminoglycans (GAG), dictates the contrast agent distribution in cartilage via electrostatic repulsion [1]. The aim of the present study was to investigate the diffe...

Background Recent work demonstrated the feasibility of using realtime MRI to guide right heart cardiac catheterization. In order to make balloon catheters used in the procedure more conspicuous, the balloons were filled with dilute Gd-DTPA, and non-selective saturation pulses were applied along with acquisition of thick slices. The saturation pulses increased the contrast between blood and the ...

Introduction: Pyeloplasty has success rate of up to 98%. We believe that paediatric pyeloplasty even in poorly functioning kidney, will result maximum salvage renal function. The aim our study was evaluate the outcome kidneys with PUJO population. Methods: children a GFR < 30 ml / min or 30% differential function on DTPA, who underwent NU hospitals, Bengaluru over period 11 years 2 months, w...

MRI of brain tumors was performed with CPMG pulse sequence, and T1 and T2 relaxation times were measured before and after the administration of 0.1 mmol/kg Gd-DTPA. T1 and T2 became significantly shorter than before with the T1 shortening being about twice the T2's. Three types of T2 shortening were classified by the difference in the intra-tumoral transport of Gd-DTPA in the time-course study ...