Controlled ovarian hyperstimulation (COH) is widely used in assisted reproductive technology (ART), but it often leads to precocious maturation of the endometrium such that it impairs embryonic implantation and limits pregnancy rates. Previous studies have shown the traditional Chinese medicine, the Zishen Yutai pill (ZYP), to be effective in treatment of threatened as well as recurrent miscarr...

Endometrial sonographic and color doppler features can be used to predict the occurrence of pregnancy in natural or stimulated cycles. Implantation will usually only take place if the endometrium has reach a certain stage of vascularisation and development. The aim of this study was to evaluate endometrial development -- endometrial thickness and reflectivity , subendometrial, endometrial and u...

The human endometrium undergoes to a complex series of proliferative and secretory changes in each menstrual cycle and displays only a short period of receptivity, known as the “window of implantation”, necessary for the implantation of the blastocyst in the uterus. The implantation process occurs in a sequential manner, leading to the establishment of pregnancy. Morphofunctional changes during...

Endometrial receptivity is highly correlated with the implantation rate, whereby in Indonesia, rate among vitro fertilisation programs still low, around 19.3%. Antagonist ovarian stimulation protocol can disrupt physiological endocrine milieu by presence of supra-physiological levels estrogen and progesterone, both which are thought to indirectly affect expression adhesion molecule cells. Homeo...

BACKGROUND Successful implantation requires a receptive endometrium. We hypothesized that effects of endometrial stromal cells (ESC) on epithelial cell receptivity and trophoblast-endometrium interaction are menstrual cycle dependent. METHODS An endometrial in vitro 3D co-culture model of primary human ESC with the endometrial epithelial cell line (RL95-2) was constructed. Co-cultures were pr...

BACKGROUND The pregnancy rate during in-vitro fertilization (IVF) following progesterone supplement still remains very low at around 20%. OBJECTIVE To investigate the effects of peanut oil itself on the endometrial receptivity, the pregnancy success rate and fertility during the peri-implantation time in hyper stimulated and normal rats. MATERIALS AND METHODS Thirty-six adult Sprague Dawley...

Background: Embryo implantation is a complex biological process which requires synchronized dialogue between the receptive endometrium and blastocyst. The endometrium, however, only to embryo for very short period. Recurrent failure (RIF) major challenge in assisted reproductive techniques mainly due impaired receptivity, but there still need reliable valid clinical test assess endometrial rece...