Krox20, a zinc finger-containing transcription factor, is well known for mediating stem and progenitor cell activation differentiation in variety of tissues. In recent study, we reported the first time population epithelial-derived Krox20-expressing keratinocytes hair follicle that ultimately terminally differentiate to form structural component shaft. These Krox20-lineage cells also mediate me...

Background: Single cell transcriptomics offers an avenue for predicting, with improved accuracy, the gene networks that are involved in establishment of first direct cell–cell interactions between blastocyst and maternal luminal epithelium. We hypothesised silico modelling maternal–embryonic interface may provide a causal model these interactions, leading to identification genes associated succ...

While much work has been done in the design of biomaterials to control integrin-mediated adhesion, less emphasis put on functionalization materials with cadherin ligands. Yet, cell–cell contacts combination cell–matrix interactions are key driving embryonic development, collective cell migration, epithelial mesenchymal transition, and cancer metastatic processes, among others. This review focus...

This retrospective study surveyed the histological prevalence of 180 canine neoplasms registered during 2016-2020 in small animal hospital, Rajamangala University Technology Tawan-Ok, Chonburi, Thailand. Histopathologic diagnosis each neoplasia was performed using its published criteria. The were categorized into epithelial, mesenchymal and round-cell neoplasms. Their parameters related to sex,...

Bispecific antibodies (BsAbs) have been developed, with one antigen-binding site coordinated against the CD3 receptor (which activates cytotoxic T lymphocytes) and other specific antigens found on cancer cells (CD19, CD20, CD33, CD123, HER2, epithelial cell adhesion molecule [EpCAM], BCMA, CEA, others) [1].

glomerular development of the kidney was studied in newborn rats by electron microscopy. four different stages of glomerular development were defined: vesicle fonnation, s-shaped body stage, capillary loop fonnation, and glomerular maturation. in the fust stage, the mesenchymal cells form a spheroid mass. this is followed by the s-shaped body stage in which clefts appear in the mass. afterwards...

Epithelial tissues rely on the adhesion between participating cells to retain their integrity. The transmembrane protein E-cadherin is major that mediates homophilic neighbouring and is, therefore, one of critical components for epithelial downregulation has been described extensively as a prerequisite epithelial-to-mesenchymal transition hallmark in many types cancer. Due this clinical importa...

purpose: to evaluate the properties of cultured limbal stem cells for corneal surface reconstruction. methods: specimens of limbal explants were prepared from the eye bank of i.r. iran. the explants were cultured and expanded on acellular amniotic membrane for 21 days. the cultured cells were evaluated for expression of connexin 43 and keratinine k3 by immunocytochemistry and expression of k12 ...