Deputy practice manager Chloe Lamont talks to Helen Jones about the group activities that have boosted her colleagues’ morale during pandemic

Modern molecular biotechnology generates a great deal of intermediate information, such as transcriptional and metabolic products in bridging DNA and complex traits. In genome-wide linkage analysis and genome-wide association study, regression analysis for large-scale correlated phenotypes is applied to map genes for those by-products that are regarded as quantitative traits. For a single trait...

Gene identification represents the first step to a better understanding of the physiological role of the underlying protein and disease pathways, which in turn serves as a starting point for developing therapeutic interventions. Familial hypercholesterolemia is a hereditary metabolic disorder characterized by high low-density lipoprotein cholesterol levels. Hypercholesterolemia is a quantitativ...

Lande's equation for predicting the response of trait means to a shift in optimal trait values is tested using a stochastic simulation model. The simulated population is finite, and each individual has a finite number of loci. Therefore, selection may cause allele frequencies and distributions to change over time. Since the equation assumes constant genetic parameters, the degree to which such ...

The breeder's equation, which predicts evolutionary change when a phenotypic covariance exists between a heritable trait and fitness, has provided a key conceptual framework for studies of adaptive microevolution in nature. However, its application requires strong assumptions to be made about the causation of fitness variation. In its univariate form, the breeder's equation assumes that the tra...

The distinction between individualistic (IV) and collectivistic (CV) instrumental values was compared to the distinction between competence-related and moral personality traits. Study 1 (N=89 students) showed that IV referred mostly to competence and were self-profitable, whereas CV referred mostly to morality and were other-profitable in their nature. Therefore, IV were predicted to reach a re...

There has been considerable recent interest in factor-analytic models for the analysis of genotype by environment type problems. It is shown that, compared to ‘standard’ multivariate analyses, such models can substantially reduce computational requirements for international genetic evaluation of beef cattle, fitting an animal model and treating performance in different countries as separate tra...