Fragment-based screening for lead generation has seen tremendous growth and success in the last few years. Furthermore, the careful design of fragment libraries has ensured both that the coverage of chemical space is as great as possible and also that the included fragments have desirable physical properties. This particular effort has thus enhanced the advantages of a fragment-based approach. ...

This contribution presents a review of our present theoretical as well as experimental knowledge of different fluctuation observables relevant to nuclear multifragmentation. The possible connection between the presence of a fluctuation peak and the occurrence of a phase transition or a critical phenomenon is critically analyzed. Many different phenomena can lead both to the creation and to the ...

Based on a general approach to binary systems we show that in low density region asymmetric nuclear matter (ANM) is unstable only against isoscalarlike fluctuations. The physical meaning of the thermodynamical chemical and mechanical instabilities is related to the inequality relations verified by the strength of interaction among different components. Relevance of these results in bulk and nec...

This research is aimed to analyze sentence fragments in a comic. The main questions raised this paper are: What types of can be seen comic Hunter X by Yoshihiro Togashi 1998? factor found uses the qualitative method conduct content and document analysis (Choy & Clark, 2010). source data was entitled ‘Hunter which researchers discovered six forms Sentence Fragments after studying data: adjec...

a polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) test was performed to investigate the allele frequencies of the insulin-like growth factor (igf1 and igf2 genes) in 90 broilerchickens. a 793 bp fragment of igf1 gene and 1146 bp fragment of igf2 gene were amplified and digested with hinfi and hsp92ii restriction enzymes,respectively. two types of alleles of a and b...

With complex systems such as spacecraft, we often need to achieve goals even though failures prevent the exact state of the system from being determined. Conformant planning is the problem of generating a plan that moves a system from any of a number of possible initial states to a goal state, given that actions may have uncertain outcomes and sensing is unavailable. Two existing approaches to ...