Familial adenomatous polyposis (FAP) is responsible for <1% of colorectal cancer (CRC) cases and is inherited as an autosomal dominant trait. Patients generally present hundreds to thousands of adenomas and develop colorectal cancer by age 35- 40 if left untreated. Here we report four patients with germline frameshift mutation (small deletion) at exon 15 of adenomatous polyposis coli (APC) tumo...

Abstract. Ishak I. 2023. Genetic variability of mutant rice (Oryza sativa) genotype induced by gamma rays. Biodiversitas 24: 3300-3306. Rice seeds Sidenuk cultivars were irradiated rays creating a broad spectrum genetic among individual plants at M3 generation progeny. Gamma Irradiated created Mutation the somatic cells population in mature embryos M1 generations. Somatic cell mutation influenc...

the aim of the present study was to find the best or optimum topology of six chicken populations, which were genotyped based on nine highly polymorphic microsatellite markers. to reach this goal, different genetic distances based on infinite allele model (iam), stepwise mutation model (smm) and drawing phylogentic trees on un-weighted pair-group method using arithmetic averages (upgma) method w...

Recently introduced, evolutionary ontologies represent a new concept as a combination of genetic algorithms and ontologies. We have defined a new framework comprising a set of parameters required for any evolutionary algorithm, i.e. ontological space, representation of individuals, the main genetic operators such as selection, crossover, and mutation. Although a secondary operator, mutation pro...

background: there are no data on the frequency and biochemical expression of the hemochromatosis associated mutations, c282y and h63d, in iranian adult population. this is the first study among iranians that may advocate a screening program. materials and methods: we investigated the frequency of the c282y/h63d hfe gene mutations in a group of 1029 randomly selected iranian blood donors as well...

cystic fibrosis (cf) is the most common inherited disorder in caucasian populations, with over 1400 cystic fibrosis transmembrane conductance regulator (cftr) mutations. the type of mutations and their distributions varies widely between different countries and/or ethnic groups. seventy iranian cystic fibrosis patients were screened for the cftr gene mutation using arms/pcr (amplification refra...

background: for screening sequence variations in genes, rapid turnover time is of fundamental importance. while, many of the current methods are unfortunately time consuming and technically difficult to implement. denaturing high-performance liquid chromatography (dhplc) method had been shown to be a high-throughput, time saving, and economical tool for mutation screening. objective: in the pre...

The data communication has been growing in present day. Therefore, the encryption became very essential secured transmission and storage protecting contents from intruder unauthorized persons. In this paper, a fast technique for text depending on genetic algorithm is presented. approach achieved by operators Crossover mutation. proposal based dividing plain characters into pairs, applying cross...

Objective(s): Granular and lattice corneal dystrophies (GCDs & LCDs) are autosomal dominant inherited disorders of the cornea. Due to genetic heterogeneity and large genes, unraveling the mutation is challenging.Materials and Methods: Patients underwent comprehensive clinical examination, and targeted next-generation sequencing (NGS) was...

Increasing of net energy storage (Q net) and discharge time of phase change material (t PCM), simultaneously, are important purpose in the design of solar systems. In the present paper, Multi-Objective (MO) based on hybrid of Particle Swarm Optimization (PSO) and multiple crossover and mutation operator is used for Pareto based optimization of solar systems. The conflicting objectives are Q net...