Introduction: Cyclophosphamide is a chemotherapy drug with several side effects on various organs such as male reproductive system that can cause infertility. In this study, we assessed combined effect of ginger and pumpkin extractson rat testis after CP injection. Methods: Forty adult male rats were randomly divided into 4 groups: The control group received intraperitoneal injection of ...

Cerebral ischemia is known to produce brain damage and related behavioral deficits including memory. Recently, accumulating lines of evidence showed that dietary enrichment with nutritional antioxidants could reduce brain damage and improve cognitive function. In this study, possible protective effect of Zingiber officinale, a medicinal plant reputed for neuroprotective effect against oxidative...

This study aimed at determining if synovial cell cultures from rheumatoid arthritis (RA), osteoarthritis (OA), and healthy controls (HC) differ and are suitable disease models in pharmacological studies, and tested their response to some anti-inflammatory drugs. Synovial cells were isolated from synovial membrane or joint fluid. Cells were cultivated and exposed to no or TNF-α stimulation witho...

This study evaluated the efficacy of various organic solvents (80% acetone, 80% ethanol, 80% methanol) and distilled water for extracting antioxidant phenolic compounds from turmeric, curry leaf, torch ginger and lemon grass extracts. They were analyzed regarding the total phenol and flavonoid contents, antioxidant activity and concentration of some phenolic compounds. Antioxidant activity was ...

The leukemia is considered to be one of the most frequent tumors in childhood. The first line of its treatment is 6-mercaptopurine (6-MP). There are many recorded cytotoxic effects for 6-mercaptopurine on tissues such as liver, pancreas and bone marrow. Nowadays the needs for administration of cytotoxic drugs are increased as the incidence of malignancies increases. So we have to search for a s...

The rhizome of ginger (Zingiber officinale) is employed in Asian traditional medicine to treat mild forms of rheumatoid arthritis and fever. We have profiled ginger constituents for robust effects on proinflammatory signaling and cytokine expression in a validated assay using human whole blood. Independent of the stimulus used (LPS, PMA, anti-CD28 Ab, anti-CD3 Ab, and thapsigargin), ginger cons...

In the present study, the hypoglycaemic potentials of ginger (Zingiber officinale) were studied in rats (four groups: control, ginger, diabetics and diabetics treated with ginger). Ginger extract was daily orally administered (400 mg/kg,) for 4 weeks to alloxan-induced diabetic rats (150 mg/kg). Fasting blood serum was analysed for blood glucose, insulin, creatinine, blood urea nitrogen, aspart...

The present study aimed to examine the antiproliferative potentiality of an extract derived from the medicinal plant ginger (Zingiber officinale) on growth of breast cancer cells. Ginger treatment suppressed the proliferation and colony formation in breast cancer cell lines, MCF-7 and MDA-MB-231. Meanwhile, it did not significantly affect viability of nontumorigenic normal mammary epithelial ce...