نتایج جستجو برای: gp1
تعداد نتایج: 282 فیلتر نتایج به سال:
Introduction: Nitric oxide (NO) is a second messenger that regulates neurotransmitter release at the neuromuscular junction (nmj). Evidences accumulate on its potency as a neuro-modulator in CNS, PNS. This work investigates the effect of NO on (nmj) by adding L-arginine known as NO donor. Material and Methods: 30 albino rats’ diaphragms divided into two groups. Both exposed to L-argnine followe...
Human infection by Marburg (MBG) or Ebola (EBO) virus is associated with fatal haemorrhagic fevers. While these filoviruses may both incite disease as a result of explosive virus replication, we hypothesized that expression of individual viral gene products, such as the envelope glycoprotein (GP), may directly alter target cells and contribute to pathogenesis. We found that expression of EBO GP...
The filoviruses, including Marburg and Ebola, express a single glycoprotein on their surface, termed GP, which is responsible for attachment and entry of target cells. Filovirus GPs differ by up to 70% in protein sequence, and no antibodies are yet described that cross-react among them. Here, we present the 3.6 Å crystal structure of Marburg virus GP in complex with a cross-reactive antibody fr...
Fragile X syndrome is the most common inherited form of cognitive deficiency in humans and perhaps the best-understood single cause of autism. A trinucleotide repeat expansion, inactivating the X-linked FMR1 gene, leads to the absence of the fragile X mental retardation protein. FMRP is a selective RNA-binding protein that regulates the local translation of a subset of mRNAs at synapses in resp...
Let X ⊂ P be a nondegenerate projective variety and let νl : P r → P be the l-th Veronese embedding. In this paper we study the higher normality, defining equations and syzygies among them for the projective embedding νl(X) ⊂ P N . We obtain that for a very ample line bundle L ∈ PicX such that X ⊂ PH(X,L) is m-regular in the sense of Castelnuovo-Mumford, (X,L) satisfies property Nl for all l ≥ ...
The aim of the research was to show our diagnostic and therapeutic experience with antiphospholipid syndrome (APS) in pregnant women. 36 pregnant women suspect on APS were included in the study: 32 with primary antiphospholipd syndrome (PAPS) and 4 with secondary antiphospholipid syndrome (SAPS). All pregnant women received low-molecular-weight-heparin (LMWH) and low dose aspirin (LDA) therapy....
Ebola virus infections cause a deadly hemorrhagic disease for which no vaccines or therapeutics has received regulatory approval. Here we show isolation of three (Q206, Q314 and Q411) neutralizing monoclonal antibodies (mAbs) against the surface glycoprotein (GP) of Ebola virus identified in West Africa in 2014 through sequential immunization of Chinese rhesus macaques and antigen-specific sing...
Thrombus formation can lead to heart attacks, stroke and pulmonary embolism, which are major causes of mortality. Current standard diagnostic imaging methods detect anatomic abnormalities such as vascular flow impairment but have limitations. By using a targeted molecular imaging approach critical components of a pathology can be selectively visualized and exploited for an improved diagnosis an...
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