نتایج جستجو برای: gp1

تعداد نتایج: 282  

2016
Lisa H. Cazares Michael D. Ward Ernie Brueggemann Tara Kenny Paul Demond Chris Mahone Karen A.O. Martins Jonathan E. Nuss Trevor Glaros Sina Bavari

31 Background: Ebola virus like particles; (EBOV VLPs, eVLPs), are produced by expressing the 32 viral transmembrane glycoprotein (GP) and the structural matrix protein VP40 in mammalian 33 cells. When expressed, these proteins self-assemble and bud from ‘host’ cells displaying 34 morphology similar to infectious virions. Several studies have shown that rodents and non35 human primates vaccinat...

Journal: :The Journal of biological chemistry 2006
Jens H Kuhn Sheli R Radoshitzky Alexander C Guth Kelly L Warfield Wenhui Li Martin J Vincent Jonathan S Towner Stuart T Nichol Sina Bavari Hyeryun Choe M Javad Aman Michael Farzan

The GP(1,2) envelope glycoproteins (GP) of filoviruses (marburg- and ebolaviruses) mediate cell-surface attachment, membrane fusion, and entry into permissive cells. Here we show that a 151-amino acid fragment of the Lake Victoria marburgvirus GP1 subunit bound filovirus-permissive cell lines more efficiently than full-length GP1. An homologous 148-amino acid fragment of the Zaire ebolavirus GP...

Journal: :Human molecular genetics 2017
Dai-Chi Liu Joseph Seimetz Kwan Young Lee Auinash Kalsotra Hee Jung Chung Hua Lu Nien-Pei Tsai

Activating Group 1 (Gp1) metabotropic glutamate receptors (mGluRs), including mGluR1 and mGluR5, elicits translation-dependent neural plasticity mechanisms that are crucial to animal behavior and circuit development. Dysregulated Gp1 mGluR signaling has been observed in numerous neurological and psychiatric disorders. However, the molecular pathways underlying Gp1 mGluR-dependent plasticity mec...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2017
Andrew Stephens

Thromboembolic diseases such as myocardial infarction, stroke, transient ischemic attacks, and pulmonary embolism are major causes of morbidity and mortality worldwide. Glycoprotein IIb/IIIa (GPIIb/IIIa) is the key receptor involved in platelet aggregation and is a validated target for therapeutic approaches and diagnostic imaging. The aim of this study was to develop and characterize a specifi...

Journal: :Gut 2001
R Rolla D Vay E Mottaran M Parodi M Vidali M Sartori C Rigamonti G Bellomo E Albano

BACKGROUND Circulating antiphospholipid antibodies (aPL) are often detected in patients with alcoholic liver disease (ALD) but little is known about the causes of their formation. AIMS We have evaluated whether ethanol mediated oxidative injury might promote the development of aPL in ALD. PATIENTS AND METHODS IgG against beta(2) glycoprotein 1 (beta(2)-GP1), cardiolipin, and human serum alb...

2011
Sheli R. Radoshitzky Lindsay E. Longobardi Jens H. Kuhn Cary Retterer Lian Dong Jeremiah C. Clester Krishna Kota John Carra Sina Bavari

Machupo virus (MACV) is a highly pathogenic New World arenavirus that causes hemorrhagic fever in humans. MACV, as well as other pathogenic New World arenaviruses, enter cells after their GP1 attachment glycoprotein binds to their cellular receptor, transferrin receptor 1 (TfR1). TfR1 residues essential for this interaction have been described, and a co-crystal of MACV GP1 bound to TfR1 suggest...

Journal: :Journal of molecular biology 2012
Haiyan Zhao Yvonne N Kamau Theodore E Christensen Liang Tang

In many DNA viruses, genome packaging is initiated by the small subunit of the packaging terminase, which specifically binds to the packaging signal on viral DNA and directs assembly of the terminase holoenzyme. We have experimentally mapped the DNA-interacting region on Shigella virus Sf6 terminase small subunit gp1, which occupies extended surface areas encircling the gp1 octamer, indicating ...

Journal: :Journal of virology 2015
Hadas Cohen-Dvashi Nadav Cohen Hadar Israeli Ron Diskin

UNLABELLED Lassa virus is a notorious human pathogen that infects many thousands of people each year in West Africa, causing severe viral hemorrhagic fevers and significant mortality. The surface glycoprotein of Lassa virus mediates receptor recognition through its GP1 subunit. Here we report the crystal structure of GP1 from Lassa virus, which is the first representative GP1 structure for Old ...

Journal: :Genes & genetic systems 2012
Takahiro Tone Ari Takeuchi Osamu Makino

Gene 1 product (gp1) of Bacillus subtilis phage φ29 has been shown to be involved in viral DNA replication in vivo, but the essential role is still unknown. As part of an ongoing effort to understand the role of gp1 in viral DNA replication, we investigated genetic interaction between gene 1 and other viral genes. Because φ29 mutants which do not produce functional gp1 show temperature-sensitiv...

Journal: :Circulation 2001
S Hörkkö T Olee L Mo D W Branch V L Woods W Palinski P P Chen J L Witztum

BACKGROUND We recently suggested that many anticardiolipin antibodies bind only to oxidized cardiolipin (OxCL) and/or to OxCL-beta(2)-glycoprotein 1 (beta(2)GP1) adducts but not to a "reduced" cardiolipin that is unable to undergo oxidation. To test this hypothesis, we investigated 24 sera, 4 protein A-purified IgG fractions, and 3 human monoclonal antibodies that were all isolated from patient...

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