New N,N-disubstituted β-amino acids and their derivatives with thiazole, aromatic, and heterocyclic substituents were synthesized from N-phenyl-N-thiocarbamoyl-β-alanine by the Hantzsch method; derivatives with hydrazone fragments were also obtained. Some of the synthesized compounds exhibited discrete antimicrobial activity, and 3-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)(phenyl)amino]propanoic ac...

By utilizing Hantzsch esters as the hydrogen source, asymmetric transfer hydrogenation of C=C, C=N, and C=O is realized in the presence of an organocatalyst or a metal-ligand complex, thus affording versatile chiral building blocks in high yields with excellent enantioselectivities under mild conditions. A detailed discussion of recent findings and an assessment of this biomimetic approach are ...

In our research, new bis-α, β-unsaturated carbonyl compounds (Z2-Z4) were prepared via Claisen- Schmidt reaction, by the condensation of 2,6-dimethyl-3,5-diacetyl-1,4-dihydropyridine (Z1) with different appropriate benzaldehyde, like (benzaldehyde, m-nitro benzaldehyde and o-chloro benzaldehyde) using 10% aqueous sodium hydroxide as a base. A simple efficient method has been applied for synthes...

We describe an assay for ethylene glycol in serum, which is based on the Hantzsch condensation reaction. Ethylene glycol is dehydrogenated by sodium periodate to form two molecules of formaldehyde, which is then combined with ammonium ion and acetylacetone to form a fluorescent diacetyllutidine derivative. The detection limit of this method is 50 mg/L. The procedure is sensitive, requires only ...

New aryl-hydrazinyl-1,3-selenazole and aroyl-hydrazonyl-1,3-selenazoles were synthesized via Hantzsch type condensation reactions of selenosemicarbazides with α-halogenocarbonyl derivatives, under classical versus microwave heating conditions. Excellent yields and shorter reaction times were obtained under irradiation conditions. The structures of the synthesized compounds were assigned based o...